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Tradjenta vs. Glucophage

Tradjenta (linagliptin) is a prescription medication that's used along with a balanced diet and exercise to manage blood sugar levels in adults with Type 2 diabetes. It's a type of diabetes medication called a dipeptidyl peptidase-4 (DPP-4) inhibitor. The dose is 5 mg (1 tablet) that's taken by mouth once per day. Tradjenta (linagliptin) doesn't cause many side effects but can sometimes include runny nose, sneezing, and diarrhea. As of 2024, Tradjenta (linagliptin) is available as a brand-name medication only; there's no generic version yet.

• Improve blood sugar levels in adults with Type 2 diabetes (as an add-on to a nutritious diet and exercise routine)

• Common cold symptoms (runny nose, sneezing, coughing; 7%)
• Diarrhea (3%)
• Cough (2%)

Note: Side effects were reported by people who took Tradjenta (linagliptin) by itself or people who took Tradjenta (linagliptin) with other diabetes.

• Inflammation of the pancreas (pancreatitis)
• Risk for low blood sugar when taken with certain other diabetes medications
• Heart failure
• Severe joint pain
• Serious allergic reactions
• Severe skin reaction

Immediate-release metformin is an oral diabetes medication. It's approved for people 10 years of age and older with Type 2 diabetes. The medication belongs to the drug class called biguanides. It works best to lower blood sugar levels with a diabetes-friendly diet and exercise plan. Immediate-release metformin comes as a tablet and an oral solution. You take this medication by mouth usually two to three times a day. It's recommended to take each dosage with food to help lessen side effects like diarrhea and nausea.

• Type 2 diabetes in people ages 10 years and older

• Diarrhea (53%)
• Nausea or vomiting (26%)
• Gas (12%)
• Weakness (9%)

• Lactic acidosis
• Low vitamin B12 levels
• Low blood sugar (hypoglycemia) when taken with certain other diabetes medications