Key takeaways
Tradjenta (linagliptin) and metformin are both prescription medications used to manage Type 2 diabetes, but they belong to different medication classes. Tradjenta (linagliptin) is a dipeptidyl peptidase-4 (DPP-4) inhibitor, while metformin is a biguanide. Tradjenta is taken as a 5 mg tablet once daily, whereas metformin is typically started at 500 mg twice daily or 850 mg once daily and can go up to a maximum of 2,550 mg per day. Tradjenta is only available as a brand-name medication, while metformin is available in both generic and brand-name forms, including liquid and long-acting tablets. Common side effects of Tradjenta include cold symptoms and diarrhea, while metformin often causes stomach issues like diarrhea and nausea. Taking Tradjenta with medications like insulin and sulfonylureas increases the risk of low blood sugar. Metformin can increase your risk for lactic acidosis, especially if taken with contrast dyes used for some imaging procedures.
