Key takeaways
Tradjenta (linagliptin) and glimepiride (Amaryl) are both medications used to treat Type 2 diabetes, but they belong to different drug classes and work in distinct ways. Tradjenta is a DPP-4 inhibitor that helps your body produce more insulin and reduce sugar production by blocking the DPP-4 protein. It’s taken once daily, with or without food. Common side effects of Tradjenta include runny nose, sneezing, and diarrhea. On the other hand, glimepiride is a sulfonylurea that stimulates your pancreas to release more insulin. It’s also taken once daily but must be taken with the first main meal to prevent low blood sugar. Glimepiride is available as a lower-cost generic, while Tradjenta is only available by brand name. Both medications can interact with alcohol and other drugs, but glimepiride has a higher risk of causing low blood sugar and weight gain compared to Tradjenta.
