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Tradjenta vs. Amaryl

Tradjenta (linagliptin) is a prescription medication that's used along with a balanced diet and exercise to manage blood sugar levels in adults with Type 2 diabetes. It's a type of diabetes medication called a dipeptidyl peptidase-4 (DPP-4) inhibitor. The dose is 5 mg (1 tablet) that's taken by mouth once per day. Tradjenta (linagliptin) doesn't cause many side effects but can sometimes include runny nose, sneezing, and diarrhea. As of 2024, Tradjenta (linagliptin) is available as a brand-name medication only; there's no generic version yet.

• Improve blood sugar levels in adults with Type 2 diabetes (as an add-on to a nutritious diet and exercise routine)

• Common cold symptoms (runny nose, sneezing, coughing; 7%)
• Diarrhea (3%)
• Cough (2%)

Note: Side effects were reported by people who took Tradjenta (linagliptin) by itself or people who took Tradjenta (linagliptin) with other diabetes.

• Inflammation of the pancreas (pancreatitis)
• Risk for low blood sugar when taken with certain other diabetes medications
• Heart failure
• Severe joint pain
• Serious allergic reactions
• Severe skin reaction

Glimepiride (Amaryl) is a medication used to treat type 2 diabetes along with healthy diet and exercise. It's part of the medication class called sulfonylureas. This medication is taken by mouth, typically once daily with the first main meal. Some common side effects of glimepiride (Amaryl) include headaches and low blood sugar. Like other medications in its class, it can also cause weight gain. Glimepiride (Amaryl) is available as both a brand name (Amaryl) and generic tablet.

• Type 2 diabetes in adults

• Shakiness, anxiety, and other symptoms of low blood sugar levels (up to 20%)
• Headache (8%)
• Fever, cough, and other flu-like symptoms (5%)
• Nausea (5%)
• Dizziness (5%)

• Low blood sugar
• Serious allergic reactions
• Risk of low red blood cell count (hemolytic anemia)
• Possible risk of serious heart problems