Key takeaways
Testopel (testosterone) and Depo-Testosterone (testosterone cypionate) are both used to treat low testosterone in males, but they have some key differences. Testopel is a long-acting testosterone replacement that comes in the form of pellets implanted under the skin every 3 to 6 months, while Depo-Testosterone is an injectable form administered into the buttock muscle every 2 to 4 weeks. Testopel requires a minor surgical procedure in your provider's office to place the pellets under the skin, which can lead to risks like infection and pellet extrusion. In contrast, Depo-Testosterone can be injected at home but still requires careful administration to avoid complications. Testopel is only available as a brand medication, whereas Depo-Testosterone is available as a lower-cost generic. Both medications share similar risks, such as heart attack, stroke, and dependency.
