Key takeaways
Ramelteon (Rozerem) and Belsomra (suvorexant) are both prescription medications used to treat insomnia, but they work in different ways and have distinct characteristics. Ramelteon is a melatonin receptor agonist that mimics the natural hormone melatonin to help regulate your sleep cycle. It is not a controlled substance and is available as a generic medication. On the other hand, Belsomra is an orexin receptor antagonist that blocks the action of orexin, a chemical that promotes wakefulness. Belsomra is a Schedule IV controlled substance, meaning it has a potential for abuse and dependence, and it is only available as a brand-name medication, making it more expensive. While Ramelteon is not habit-forming, Belsomra can be addictive and is typically used for short-term treatment. Both medications should be taken 30 minutes before bedtime. Ramelteon should be taken on an empty stomach, whereas Belsomra may take longer to work if taken with food. Common side effects of Ramelteon include dizziness and sleepiness, while Belsomra can cause drowsiness the next day, abnormal dreams, and sleep paralysis.
