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Rinvoq vs. Zeposia

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Rinvoq (upadacitinib) and Zeposia (ozanimod) are both medications used to treat ulcerative colitis (UC), but they belong to different drug classes. Rinvoq is a Janus kinase (JAK) inhibitor, while Zeposia is a sphingosine 1-phosphate (S1P) receptor modulator. Rinvoq is also used for a variety of other inflammatory conditions, such as rheumatoid arthritis and eczema, whereas Zeposia is additionally approved for relapsing forms of multiple sclerosis (MS). Rinvoq is available as an extended-release tablet and an oral solution, typically taken once daily, while Zeposia is taken as a capsule once daily, with a starter pack to gradually increase the dose. Common side effects of Rinvoq include infections and acne, while Zeposia may cause upper respiratory infections and changes in liver tests. Both medications can increase the risk of infections, but Zeposia also has specific warnings about changes in heart rate and blood pressure. Both medications require careful monitoring for side effects and interactions with other medications.

Rinvoq

(upadacitinib)

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Zeposia

(ozanimod)

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Summary for Rinvoq

Prescription only

Rinvoq (upadacitinib) is a Janus kinase (JAK) inhibitor. It treats many inflammatory conditions. This includes rheumatoid arthritis (RA), ulcerative colitis (UC), Crohn's disease (CD), and eczema (atopic dermatitis). It's often used when other treatments haven't worked well. Rinvoq (upadacitinib) is taken by mouth, usually once a day. It comes as an extended-release pill (Rinvoq) and an oral solution (Rinvoq LQ). These formulations aren't the same and can't be swapped easily. Side effects include nausea and a higher risk of infection.

Indications for Rinvoq

Pros and Cons for Rinvoq

Pros

  • Can treat many different inflammatory conditions
  • Available as a tablet and a liquid
  • Tablets are taken once a day

Cons

  • Can raise your risk of infections
  • Can interact with grapefruit
  • Not the best option for people with severe liver or kidney problems

Common Side Effects for Rinvoq

Warnings for Rinvoq

  • Serious infections
  • Possible higher risk of heart attack, stroke, or heart-related death in certain older adults with RA
  • Risk of cancer
  • Risk of blood clots
  • Allergic reactions
  • Stomach damage
  • Abnormal lab results (e.g., blood counts, cholesterol)
  • Harm to an unborn baby
  • Medication in stool

Summary for Zeposia

Prescription only

Zeposia (ozanimod) treats adults with relapsing forms of multiple sclerosis (MS). This medication can also treat adults with ulcerative colitis (UC). It works as a sphingosine 1-phosphate (S1P) receptor modulator to relieve inflammation in the body. It's a capsule you take by mouth, usually once per day (or as directed by your prescriber if you have liver problems). You use a starter pack for the first week. It helps you slowly raise your dosage to a maintenance level. Side effects include upper respiratory infections and higher liver enzymes. Zeposia (ozanimod) is only available as a brand-name medication.

Indications for Zeposia

Pros and Cons for Zeposia

Pros

  • Taken by mouth, with or without food
  • Taken once a day
  • Starter pack available to help guide dosing at the beginning of treatment

Cons

  • Might raise your risk of infections
  • Not safe for people with certain heart problems or severe liver problems
  • Not approved for children

Common Side Effects for Zeposia

Warnings for Zeposia

  • Risk of infections
  • Risk of brain infection (progressive multifocal leukoencephalopathy)
  • Slow heart rate and heart rhythm
  • Higher blood pressure
  • Liver damage
  • Breathing problems
  • Eye problem called macular edema
  • Brain problem called posterior reversible encephalopathy syndrome (PRES)
  • Possible risk of skin cancer
  • Harm to an unborn baby

Prices with our coupons for Rinvoq vs. Zeposia

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Rinvoq30 tablets / 15mg
$6,244.67-
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Zeposia30 capsules / 0.92mg of
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