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Rinvoq vs. Cimzia

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Rinvoq (upadacitinib) and Cimzia (certolizumab) are both medications used to treat inflammatory conditions like rheumatoid arthritis and Crohn's disease. However, they belong to different medication classes. Rinvoq is a Janus kinase (JAK) inhibitor, while Cimzia is a tumor necrosis factor (TNF) blocker. Rinvoq is taken orally, either as an extended-release tablet or an oral solution, and is typically taken once daily. In contrast, Cimzia is administered as an injection every 2 to 4 weeks. Rinvoq is available in both tablet and liquid forms, but Cimzia is only available as an injection. Common side effects of Rinvoq include upper respiratory infections and acne, while Cimzia may cause upper respiratory infections and skin rash. Both medications can increase the risk of infections, but Rinvoq also has a risk of causing blood clots and stomach tears. Additionally, Rinvoq is not recommended during pregnancy, whereas Cimzia might be okay, depending on a risk-benefit discussion with your prescriber. It's important to discuss with your healthcare professional which medication is best for your condition and lifestyle.

Rinvoq

(upadacitinib)

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Cimzia

(certolizumab)

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Summary for Rinvoq

Prescription only

Rinvoq (upadacitinib) is a Janus kinase (JAK) inhibitor. It's used to treat certain inflammatory conditions, such as rheumatoid arthritis (RA), ulcerative colitis (UC), and eczema (atopic dermatitis). But it's not a first-choice option and typically only prescribed when other treatments haven't worked well. Rinvoq (upadacitinib) is taken by mouth, usually once daily. It's available as an extended-release tablet (Rinvoq) and an oral solution (Rinvoq LQ), but the two formulations aren't interchangeable. Side effects include a higher risk of infections, acne, and nausea.

Indications for Rinvoq

Moderate-to-severe inflammatory conditions in which other treatments haven't worked:

Pros and Cons for Rinvoq

Pros

  • Can treat many different inflammatory conditions
  • Available as a tablet and a liquid
  • The tablet only needs to be taken once a day

Cons

  • Can raise risk for infections
  • Not the best option for people with severe liver or kidney problems
  • Not safe for use during pregnancy

Common Side Effects for Rinvoq

Note: Side effects listed were reported by people who took Rinvoq for eczema.

Warnings for Rinvoq

  • Serious infections
  • Possible higher risk of death for people with rheumatoid arthritis
  • Risk of cancer
  • Possible risk of heart attack, stroke, and other blood clots
  • Severe allergic reaction
  • Stomach and gut tears
  • Abnormal lab results (e.g., blood cell counts, cholesterol levels)
  • Possible harm to unborn babies
  • Medication in stool

Summary for Cimzia

Prescription only

Cimzia (certolizumab) is a prescription biologic used to treat several autoimmune conditions, like rheumatoid arthritis, psoriatic arthritis, and Crohn's disease. It works by blocking a protein called tumor necrosis factor (TNF), which helps reduce inflammation in your body. The medication is given as an injection under the skin every 2 to 4 weeks, depending on your condition. Common side effects include upper respiratory infections, urinary tract infections (UTIs), and skin rash.

Indications for Cimzia

Pros and Cons for Cimzia

Pros

  • Treats a variety of autoimmune conditions
  • Only need to inject every 2 to 4 weeks
  • Available as a prefilled syringe for at-home administration

Cons

  • Can raise your risk for infections
  • Some people might have difficulty injecting it properly
  • Might have a higher risk for certain cancers

Common Side Effects for Cimzia

Warnings for Cimzia

  • Serious infections
  • Cancer
  • Heart failure
  • Allergic reactions
  • Nervous system problems
  • Blood problems
  • Lupus-like condition
  • Live vaccines

Prices with our coupons for Rinvoq vs. Cimzia

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Rinvoq30 tablets / 15mg
$6,243.91$8,850.61
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Cimzia1 carton / 2 prefilled syringes of 200mg/ml
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