Key takeaways
Sevelamer carbonate (Renvela) and sevelamer hydrochloride (Renagel) are both phosphate binders used to lower blood phosphate levels in people with chronic kidney disease (CKD) on dialysis. While both medications work similarly, there are some key differences. Sevelamer carbonate is available in both tablet and powder forms, making it a good option if you have trouble swallowing pills, whereas sevelamer hydrochloride is only available in tablet form. Additionally, sevelamer carbonate can be used in children as young as 6 years old, but sevelamer hydrochloride is only approved for adults. Sevelamer carbonate also has the advantage of not causing acid buildup in the body, helping to prevent a condition called metabolic acidosis. Both medications must be taken with meals to work effectively, and they share common side effects like nausea, vomiting, and diarrhea. Both medications are available as low-cost generics. However, sevelamer carbonate generally costs less, making it a more affordable option.
