Key takeaways
Sevelamer carbonate (Renvela) and ferric citrate (Auryxia) are both phosphate binders used to lower high blood phosphate levels in people with chronic kidney disease (CKD) on dialysis. However, they have some key differences. Sevelamer carbonate is available as both a tablet and a powder for suspension, making it a good option for those who have trouble swallowing pills. In contrast, ferric citrate is only available in tablet form and must be swallowed whole. Ferric citrate can also treat iron deficiency anemia in people with CKD, thanks to its iron content, which can cause stools to appear darker. Sevelamer carbonate does not have this dual function. Both medications must be taken with meals to work effectively, but ferric citrate requires frequent blood tests to monitor iron levels, which is not a concern with sevelamer carbonate. Common side effects for both include diarrhea and nausea, but ferric citrate also carries a risk of iron overload, which can be dangerous.
