Key takeaways
Reclast (zoledronic acid) and Prolia (denosumab) are both used to treat osteoporosis, but they have some key differences. Reclast is a bisphosphonate given as an intravenous (IV) infusion once a year or every two years, while Prolia is a monoclonal antibody given as an injection under the skin every six months. Reclast is available in both brand and generic forms, whereas Prolia is only available as a brand. Reclast works by slowing down bone breakdown, while Prolia blocks a protein that signals bone breakdown. Prolia can also help with bone loss due to certain cancers, which Reclast does not. Both medications can cause side effects like muscle and joint pain, but Prolia has additional risks like dangerously low calcium levels and serious infections. You need to take calcium and vitamin D supplements with both medications to help keep your bones strong.
