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Qsymia vs. Mounjaro

Qsymia (phentermine / topiramate extended release) is a combination medication used to help with weight loss. It's approved for people over 12 who are considered obese and for some adults who are considered overweight. This medication is a tablet that you take once a day. You should also eat a balanced diet and exercise regularly for best results. Side effects include a "pins-and-needles" feeling, dry mouth, and constipation. You can only get this medication through the Qsymia REMS (Risk Evaluation and Mitigation Strategies) program because of the risk of birth defects if taken during pregnancy.

• Weight loss and long-term weight management, together with diet and exercise, for certain people:
  • People age 12 years and older considered obese
  • Adults considered overweight with at least one weight-related condition (e.g., heart disease, high blood pressure, Type 2 diabetes)

Adults:

• Feeling of pins and needles (up to 20%)
• Dry mouth (up to 19%)
• Constipation (up to 16%)
• Upper respiratory tract infection (up to 16%)
• Headache (up to 11%)
• Change in taste (up to 9%)
• Trouble sleeping (up to 9%)
• Dizziness (up to 9%)

Children:

• Depression (up to 4%)
• Nausea (up to 4%)
• Fever (up to 4%)
• Dizziness (up to 4%)
• Joint pain (up to 4%)

• Harm to an unborn baby
• Mood problems and suicidal thoughts or behavior
• Fast heart beat
• Vision problems
• Problems concentrating
• Higher level of acid in blood (metabolic acidosis)
• Possible lower kidney function
• Kidney stones
• High body temperature and inability to sweat
• Serious allergic reactions and skin reactions
• Possible slowed growth in children

Mounjaro (tirzepatide) is a prescription injection used to improve blood sugar control in people 10 years and older with Type 2 diabetes. It works best when you also follow a nutritious diet and exercise regularly. Mounjaro (tirzepatide) belongs to the drug class called GIP and GLP-1 agonists. The dosage is convenient because it's injected under the skin once a week. Some common side effects of Mounjaro (tirzepatide) include nausea and diarrhea. It can also lower your appetite, which might lead to some weight loss.

• Type 2 diabetes in adults and children 10 years of age and older

• Nausea (12-18%)
• Diarrhea (12-17%)
• Low appetite (5-11%)
• Vomiting (5-9%)
• Indigestion (5-8%)
• Constipation (6-7%)
• Stomach pain (5-6%)

• Risk of thyroid cancer
• Inflammation of the pancreas (pancreatitis)
• Low blood sugar (hypoglycemia) when used with other diabetes medications
• Allergic reactions
• Stomach side effects
• Kidney damage due to dehydration
• Eye problems in people with diabetic retinopathy
• Gallbladder problems
• Lung problems during general anesthesia or deep sedation
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