Key takeaways
Prandimet (metformin/repaglinide) and acarbose are both oral medications used to control blood sugar in people with type 2 diabetes, but they work in different ways and have different availability. Prandimet combines metformin and repaglinide, which work together to lower blood sugar by increasing insulin production and reducing sugar production and absorption. However, Prandimet has been discontinued and is no longer available in the United States. On the other hand, acarbose, available only as a generic, works by blocking a protein that slows down carbohydrate digestion, leading to lower blood sugar levels after meals. Acarbose is less likely to cause hypoglycemia when used alone but can cause side effects like gas and diarrhea. Unlike Prandimet, acarbose must be taken with the first bite of each main meal and is still available by prescription.
