Key takeaways
Prandimet (metformin/repaglinide) and glyburide (Diabeta) are both oral medications used to manage type 2 diabetes, but they have some key differences. Prandimet is a combination of two drugs, metformin and repaglinide, which work together to control blood sugar by increasing insulin production and reducing sugar production and absorption. However, Prandimet has been discontinued and is no longer available in the United States. On the other hand, glyburide is a sulfonylurea that works by prompting the pancreas to release more insulin and is still available by prescription. Glyburide can be taken once or twice daily. Glyburide has a higher risk of causing low blood sugar, especially if you skip meals, and it can also lead to weight gain. Prandimet's individual components, metformin and repaglinide, are still available separately, whereas glyburide is available in both non-micronized and micronized forms, with the latter being better absorbed by the body.
