Key takeaways
Clopidogrel (Plavix) and Pradaxa (dabigatran) are both medications used to prevent heart attacks and strokes, but they work differently and have some key differences. Clopidogrel is a P2Y12 prevents platelets from clumping together, while Pradaxa is a direct thrombin inhibitor that stops blood clots from forming. Both medications are available as a generic. Clopidogrel is typically taken once a day, while Pradaxa is usually taken twice a day. Unlike some other blood thinners, neither clopidogrel nor Pradaxa require regular blood tests. But Pradaxa must be used carefully in people with kidney problems. Both medications can increase the risk of bleeding, but Pradaxa has a higher risk of stomach bleeding and isn’t safe for people with artificial heart valves. Clopidogrel interacts with many other medications and shouldn’t be taken with grapefruit juice, while Pradaxa has fewer dietary restrictions.
