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Praxbind
Praxbind (idarucizumab) is a rescue medication used to reverse the effects of Pradaxa (dabigatran) for people who require emergent surgery or who have a life-threatening bleed. It's given by a trained healthcare provider as an injection through the vein.
Last reviewed on May 24, 2022
What is Praxbind (idarucizumab)?
How Praxbind (idarucizumab) works
Drug Facts
Common BrandsPraxbind
Drug ClassAntidote
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
Frequently asked questions about Praxbind (idarucizumab)
What is Praxbind (idarucizumab) used for?
Praxbind (idarucizumab) is a medication used to reverse the anticoagulant (blood-thinning) effects of Pradaxa (dabigatran). It's used in people taking Pradaxa (dabigatran) regularly who need to have an emergency surgery or procedure done or who are having life-threatening or uncontrolled bleeding.
How does Praxbind (idarucizumab) work?
Praxbind (idarucizumab) is a reversal agent (antidote). It works by attaching to Pradaxa (dabigatran) to inactivate it. This prevents Pradaxa (dabigatran) from working in your body.
How much Praxbind (idarucizumab) will I receive, and how is it given?
The total dose of Praxbind (idarucizumab) is 5 grams injected through the vein (intravenous, IV) as a single dose. Each vial of Praxbind (idarucizumab) contains 2.5 grams of medication, meaning it takes two vials to give the full dose. Your provider will give you your full dose as either two consecutive (one after the other) infusions or as two consecutive, quick injections with a syringe.
Does Praxbind (idarucizumab) work to stop bleeding from other anticoagulants?
No, Praxbind (idarucizumab) is specifically used to reverse the effects of Pradaxa (dabigatran) only. There are other reversal agents available for other anticoagulants that are commonly used today.
What are the side effects of Praxbind (idarucizumab)?
Since Praxbind (idarucizumab) reverses the anticoagulant effect of Pradaxa (dabigatran), there's a risk for blood clots. After receiving Praxbind (idarucizumab), your provider will determine whether you still need an anticoagulant like Pradaxa (dabigatran) or not. If your provider says it's safe for you to continue taking Pradaxa (dabigatran), you'll likely start taking it again 24 hours after you receive Praxbind (idarucizumab). Other side effects of Praxbind (idarucizumab) include headache, constipation, and nausea.
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