Praxbind
Praxbind (idarucizumab) is a rescue medication used to reverse the effects of Pradaxa (dabigatran) for people who require emergent surgery or who have a life-threatening bleed. It's given by a trained healthcare provider as an injection through the vein.
What is Praxbind (idarucizumab)?
Drug facts
Common questions about Praxbind (idarucizumab)
Praxbind (idarucizumab) is a medication used to reverse the anticoagulant (blood-thinning) effects of Pradaxa (dabigatran). It's used in people taking Pradaxa (dabigatran) regularly who need to have an emergency surgery or procedure done or who are having life-threatening or uncontrolled bleeding.
Praxbind (idarucizumab) is a reversal agent (antidote). It works by attaching to Pradaxa (dabigatran) to inactivate it. This prevents Pradaxa (dabigatran) from working in your body.
The total dose of Praxbind (idarucizumab) is 5 grams injected through the vein (intravenous, IV) as a single dose. Each vial of Praxbind (idarucizumab) contains 2.5 grams of medication, meaning it takes two vials to give the full dose. Your provider will give you your full dose as either two consecutive (one after the other) infusions or as two consecutive, quick injections with a syringe.
No, Praxbind (idarucizumab) is specifically used to reverse the effects of Pradaxa (dabigatran) only. There are other reversal agents available for other anticoagulants that are commonly used today.
Since Praxbind (idarucizumab) reverses the anticoagulant effect of Pradaxa (dabigatran), there's a risk for blood clots. After receiving Praxbind (idarucizumab), your provider will determine whether you still need an anticoagulant like Pradaxa (dabigatran) or not. If your provider says it's safe for you to continue taking Pradaxa (dabigatran), you'll likely start taking it again 24 hours after you receive Praxbind (idarucizumab). Other side effects of Praxbind (idarucizumab) include headache, constipation, and nausea.
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