Key takeaways
Nortriptyline (Pamelor) and protriptyline (Vivactil) are both tricyclic antidepressants (TCAs) used to treat depression, but they have some differences. Nortriptyline is available in both capsule and liquid forms, while protriptyline is only available as a generic tablet. Nortriptyline is generally well-tolerated and might have fewer side effects compared to other TCAs, whereas protriptyline is less commonly used today due to its many side effects, such as headache, blurry vision, and restlessness. Nortriptyline can also be used off-label for chronic pain and nerve pain, while protriptyline is not typically used for these conditions. Both medications typically need to be taken multiple times a day, up to four times daily. Both medications carry risks of serious side effects, including suicidal thoughts and heart problems.
