Key takeaways
Ketoconazole and butenafine (Lotrimin Ultra) are both antifungal medications, but they differ in their application and specific uses. Ketoconazole is an oral azole antifungal used for serious systemic fungal infections, while butenafine is a topical antifungal cream used for skin infections like athlete's foot, jock itch, and ringworm. Ketoconazole is available by prescription only and is typically taken once daily, whereas butenafine is available over-the-counter and applied directly to the skin once or twice daily. Ketoconazole can cause serious side effects, including liver damage and heart rhythm problems, and interacts with many medications. In contrast, butenafine's side effects are generally limited to skin irritation at the application site. Ketoconazole is a last-choice option due to its risks, while butenafine is a more accessible and safer choice for common skin fungal infections.
