Key takeaways
Neosporin (bacitracin/neomycin/polymyxin B) and neomycin/polymyxin B/hydrocortisone (formerly Cortisporin) are both used to treat infections, but they have different uses and formulations. Neosporin is a topical antibiotic ointment available over the counter, used to prevent infections in minor cuts, scrapes, and burns. It combines three antibiotics to kill bacteria. In contrast, neomycin/polymyxin B/hydrocortisone is a prescription ear drop that treats outer ear infections and includes two antibiotics and a corticosteroid to reduce swelling and itching. While Neosporin is applied to the skin, neomycin/polymyxin B/hydrocortisone is specifically for the ears and should not be used in the eyes. Neosporin is convenient for minor skin injuries, whereas neomycin/polymyxin B/hydrocortisone is more specialized for ear infections and requires careful administration to avoid contamination. Both medications have generic versions available, making them more affordable.
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