Head-to-head comparisons of medication uses, side effects, warnings, and more.
Key takeaways
Silver sulfadiazine (SSD) and Polysporin (bacitracin/polymyxin B) are both topical antibiotics, but they have different uses and availability. Silver sulfadiazine (SSD), available under brands like Silvadene and Thermazene, is a prescription-only cream used to treat or prevent infections in second- and third-degree burns. It works by damaging the protective coverings of bacteria. On the other hand, Polysporin, which contains bacitracin and polymyxin B, is an over-the-counter ointment used to prevent infections in minor cuts, scrapes, and burns. While SSD is typically applied once or twice a day, Polysporin can be used up to three times daily. SSD is not recommended for pregnant women close to their due dates or for babies under two months old, whereas Polysporin is generally safe for most people if used as directed. Additionally, SSD can cause more severe side effects like serious allergic reactions and changes in blood cell levels, while Polysporin's side effects are usually limited to minor skin rashes and itching.
Silver sulfadiazine (SSD)
Polysporin (bacitracin / polymyxin B)
Silver sulfadiazine (SSD)
Polysporin (bacitracin / polymyxin B)
Summary of Ssd vs. Polysporin
Summary for Antibiotic
Prescription only
Silver sulfadiazine (SSD) is an antibiotic cream used to treat or prevent serious skin infections caused by second- or third-degree burns. Silver sulfadiazine (SSD) is typically applied once or twice a day, after the wound has been cleaned. This medication can cause some side effects, such as rash or skin redness. Rarely, it can lead to serious allergic reactions. Silver sulfadiazine (SSD) is available by prescription only.
Summary for Topical antibiotic
Polysporin (bacitracin / polymyxin B) is a combination medication that contains two antibiotics. It's an ointment that's applied on the skin to prevent bacterial infections in minor cuts and burns. Typically, you can apply this medication onto your skin 1 to 3 times daily. Most people have few to no side effects when they use Polysporin (bacitracin / polymyxin B) as directed.
Indications of Ssd vs. Polysporin
Indications for
•Prevention and treatment of infections caused by second- and third-degree burns
Indications for
•Preventing bacterial skin infections from small cuts, scrapes, and burns
Pros and Cons of Ssd vs. Polysporin
Pros and Const for Antibiotic
Pros
•Works well against many different kinds of bacteria