Key takeaways
Lyllana (estradiol patch) and Divigel (estradiol gel) are both estrogen replacement therapies used to treat menopausal symptoms, such as hot flashes and night sweats. They are similar in that they both contain estradiol, a type of estrogen, and are used to relieve symptoms of menopause. However, they differ in their application methods and dosing schedules. Lyllana is a transdermal patch applied twice a week to the lower stomach or buttocks, while Divigel is a topical gel applied daily to the upper thigh. Lyllana is specifically indicated for preventing osteoporosis after menopause, whereas Divigel is not. Both medications are available by prescription only, but Divigel is available in both brand-name and generic forms. Common side effects of Lyllana include headaches and breast tenderness, while Divigel may cause vaginal yeast infections and abnormal vaginal bleeding. Both medications carry risks of serious side effects like blood clots and certain cancers, and they may require the addition of a progestin if you have a uterus.
