Key takeaways
Lunesta (eszopiclone) and Belsomra (suvorexant) are both medications used to treat insomnia, but they work in different ways and have some distinct differences. Lunesta is a sedative-hypnotic that may interact with GABA proteins in the brain to help you feel calmer and sleepier. It is available as a lower-cost generic and is typically taken right before bedtime. On the other hand, Belsomra is an orexin receptor antagonist that blocks the action of orexin, a chemical that promotes wakefulness and is only available as a brand-name medication. While both medications are controlled substances with potential for misuse, Belsomra is noted for its risk of causing sleep paralysis and muscle weakness in the legs, which are not common with Lunesta. Additionally, Lunesta can cause a bad taste in your mouth and has a risk of abnormal sleep behaviors like sleepwalking, whereas Belsomra may lead to vivid dreams and memory problems. Both medications should be taken with caution, especially if you have a history of depression or other mental health issues.
