Key takeaways
Linzess (linaclotide) and Kristalose (lactulose) are both medications used to treat constipation, but they have some key differences. Linzess is a guanylate cyclase-C (GC-C) agonist that helps increase fluid in the intestines and speeds up food movement, making it effective for irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC). It's taken as a capsule once daily on an empty stomach. On the other hand, Kristalose is an osmotic laxative that draws fluid into the gut to soften stools and is taken as a powder dissolved in water. While Linzess is only available as a brand medication, Kristalose is a specific brand of lactulose, which is available in other forms. Linzess can cause severe diarrhea and dehydration, especially in children under 2. Kristalose, on the other hand, may cause gas, stomach cramps, and potential dehydration if used long-term. Additionally, Kristalose contains sugars that may affect blood sugar levels, which is a consideration for people with diabetes.
