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Latuda vs. Vraylar

Latuda, also known by its generic name lurasidone, is a type of atypical antipsychotic. It's used to treat schizophrenia in adults and teens. It can also help with depression from bipolar disorder in people 10 years and older. Latuda (lurasidone) comes as a tablet that you swallow whole once a day with food (at least 350 calories). The most common side effect is sleepiness. This medication isn't likely to cause weight gain. Latuda (lurasidone) is available as brand-name and generic versions.

• Schizophrenia in people 13 years and older
• Depression from bipolar 1 disorder in people 10 years and older
• Depression from bipolar 1 disorder in adults - as add-on therapy to lithium or divalproex (Depakote)

• Sleepiness
• Nausea
• Movement problems (e.g., tremors, slow movement, stiff muscles)
• Can't stay still (restlessness)

• Risk of suicidal thoughts and behavior
• Higher risk of death in older people with dementia-related psychosis
• Neuroleptic malignant syndrome (NMS)
• Trouble controlling muscle movements (tardive dyskinesia)
• Changes in blood sugar levels, cholesterol, and weight
• Low blood pressure and risk of falls
• Trouble concentrating and extreme sleepiness
• High prolactin levels
• Lower white blood cell count (leading to possible risk of infection)
• Seizures
• Risk of manic episode
• Higher risk of side effects in people with Parkinson's disease or Lewy body dementia

Vraylar (cariprazine) is an atypical antipsychotic used to treat schizophrenia and bipolar I disorder in teens and adults. It can also be added to other medications to help treat depression in adults. You take a dose by mouth once a day. Common side effects include uncontrolled body movements and restlessness. Compared to some other antipsychotic medications, Vraylar (cariprazine) usually causes little to no weight gain.

• Schizophrenia - age 13 years and older
• Manic or mixed episodes of bipolar I disorder - age 10 years and older
• Bipolar depression of bipolar I disorder - adults
• Major depressive disorder (MDD), as an add-on treatment - adults

• Uncontrolled muscle movements (up to 19%)
• Trouble sleeping (up to 13%)
• Headache (up to 11%)
• Drowsiness (up to 8%)
• Constipation (up to 7%)
• Nausea (up to 7%)
• Restlessness (up to 6%)

*Note: Side effects listed were reported by people in studies who took Vraylar (cariprazine) for schizophrenia.

• Higher risk of death in older adults with dementia-related psychosis
• Suicidal thoughts and behavior
• Neuroleptic malignant syndrome
• Difficulty controlling movements (tardive dyskinesia)
• High blood sugar, high cholesterol, and weight gain
• Low white blood cell count
• Higher risk of falls and fainting
• Seizures
• Trouble controlling body temperature
• Difficulty swallowing