Compare
Latuda vs. Rexulti

Latuda, also known by its generic name lurasidone, is a type of atypical antipsychotic. It's used to treat schizophrenia in adults and teens. It can also help with depression from bipolar disorder in people 10 years and older. Latuda (lurasidone) comes as a tablet that you swallow whole once a day with food (at least 350 calories). The most common side effect is sleepiness. This medication isn't likely to cause weight gain. Latuda (lurasidone) is available as brand-name and generic versions.

• Schizophrenia in people 13 years and older
• Depression from bipolar 1 disorder in people 10 years and older
• Depression from bipolar 1 disorder in adults - as add-on therapy to lithium or divalproex (Depakote)

• Sleepiness
• Nausea
• Movement problems (e.g., tremors, slow movement, stiff muscles)
• Can't stay still (restlessness)

• Risk of suicidal thoughts and behavior
• Higher risk of death in older people with dementia-related psychosis
• Neuroleptic malignant syndrome (NMS)
• Trouble controlling muscle movements (tardive dyskinesia)
• Changes in blood sugar levels, cholesterol, and weight
• Low blood pressure and risk of falls
• Trouble concentrating and extreme sleepiness
• High prolactin levels
• Lower white blood cell count (leading to possible risk of infection)
• Seizures
• Risk of manic episode
• Higher risk of side effects in people with Parkinson's disease or Lewy body dementia

Rexulti (brexpiprazole) is an atypical antipsychotic used to treat depression and schizophrenia. It can also help manage dementia-related agitation from Alzheimer's disease. The medication works by balancing chemicals in your brain to regulate your mood. Rexulti (brexpiprazole) comes as a tablet you take by mouth, usually once a day. Common side effects include weight gain, sleepiness, and dizziness. Although generic versions have been approved, they aren't yet available in pharmacies.

• Add-on treatment for depression in adults
• Schizophrenia in adults and teens 13 years and older
• Dementia-related agitation from Alzheimer's disease

Depression

• Fidgeting (9%)
• Weight gain (7%)
• Headache (7%)
• Sleepiness (5%)

Schizophrenia

• Fidgeting (6%)

Dementia-related agitation

• Headache (8%)

• Higher risk of death in older adults with dementia-related psychosis
• Suicidal thoughts and behaviors
• Neuroleptic malignant syndrome (NMS)
• Uncontrolled body movements (tardive dyskinesia)
• High blood sugar, high cholesterol, and weight gain
• Impulse control problems
• Low white blood cell count
• Falls and fainting
• Seizures
• Trouble controlling body temperature
• Difficulty swallowing
• Problems with thinking and movement