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Latuda vs. Invega

Latuda, also known by its generic name lurasidone, is a type of atypical antipsychotic. It's used to treat schizophrenia in adults and teens. It can also help with depression from bipolar disorder in people 10 years and older. Latuda (lurasidone) comes as a tablet that you swallow whole once a day with food (at least 350 calories). The most common side effect is sleepiness. This medication isn't likely to cause weight gain. Latuda (lurasidone) is available as brand-name and generic versions.

• Schizophrenia in people 13 years and older
• Depression from bipolar 1 disorder in people 10 years and older
• Depression from bipolar 1 disorder in adults - as add-on therapy to lithium or divalproex (Depakote)

• Sleepiness
• Nausea
• Movement problems (e.g., tremors, slow movement, stiff muscles)
• Can't stay still (restlessness)

• Risk of suicidal thoughts and behavior
• Higher risk of death in older people with dementia-related psychosis
• Neuroleptic malignant syndrome (NMS)
• Trouble controlling muscle movements (tardive dyskinesia)
• Changes in blood sugar levels, cholesterol, and weight
• Low blood pressure and risk of falls
• Trouble concentrating and extreme sleepiness
• High prolactin levels
• Lower white blood cell count (leading to possible risk of infection)
• Seizures
• Risk of manic episode
• Higher risk of side effects in people with Parkinson's disease or Lewy body dementia

Invega (paliperidone) is taken by mouth and used to improve mood, thoughts, and behaviors in people who have schizophrenia or schizoaffective disorder. It's available as both brand and generic versions in an extended-release pill, which means the medication is released slowly in your body. It only needs to be taken once a day. Some common side effects include drowsiness and uncontrolled muscle movements. There are long-acting injection forms of this medication available given by a trained healthcare provider.

• Schizophrenia
• Schizoaffective disorder

• Abnormal muscle movements (up to 40%)
• Drowsiness (up to 26%)
• Headache (up to 14%)
• Irregular heart beat (up to 14%)
• Vomiting (up to 11%)
• Anxiety (up to 9%)

• Higher risk of death in older adults with dementia-related psychosis
• Neuroleptic malignant syndrome (NMS)
• High blood sugar, high cholesterol, and weight gain
• Difficulty controlling muscle movements (tardive dyskinesia)
• Higher risk of falls
• High prolactin levels
• Higher risk of infections
• Not for people with gut problems
• Heart rhythm problem (QT prolongation)