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Foundayo vs. Rybelsus

Foundayo (orforglipron) is an oral glucagon-like peptide-1 (GLP-1) receptor agonist. It's approved for weight loss in certain adults. This medication is meant to be used together with a reduced-calorie diet and exercise. Foundayo (orforglipron) comes as tablets and is taken by mouth once a day with or without food. The dose is slowly raised over several weeks. Common side effects include nausea, constipation, and diarrhea.

• Weight loss and long-term weight management in adults who are considered obese or overweight with at least one weight-related condition

• Nausea (26-35%)
• Constipation (20-27%)
• Diarrhea (21-25%)
• Vomiting (13-24%)
• Indigestion (12-16%)
• Stomach pain (13-14%)
• Headache (8-9%)
• Bloating (7-9%)
• Feeling tired (6-9%)
• Belching (6-8%)
• Gastroesophageal reflux disease (GERD; 6-7%)
• Having a lot of gas (5-6%)
• Hair loss (4-5%)

• Possible risk of thyroid cancer
• Severe stomach side effects
• Kidney damage
• Inflammation of the pancreas (pancreatitis)
• Gallbladder problems
• Low blood sugar
• Allergic reactions
• Eye problems in people with Type 2 diabetes (diabetic retinopathy)
• Lung problems during general anesthesia or deep sedation

Rybelsus (semaglutide) is a brand-name GLP-1 agonist that helps lower blood sugar in adults with Type 2 diabetes. It's also FDA approved to help reduce the risk of heart attack, stroke, and heart-related death in people with Type 2 diabetes who are at risk for these events. You take it as a pill once a day, at least 30 minutes before eating, drinking, or taking other medicatons by mouth. It’s used along with diet and exercise, and might also help with weight loss. Common side effects include nausea, stomach pain, and diarrhea.

• Type 2 diabetes
• Lower the risk of heart attack, stroke, and heart-related death in adults with Type 2 diabetes at high risk for these events

• Nausea (11-20%)
• Stomach pain (10-11%)
• Diarrhea (9-10%)
• Lower appetite (6-9%)
• Vomiting (6-8%)
• Constipation (5-6%)

• Risk of thyroid tumors
• Inflammation of the pancreas (pancreatitis)
• Eye problems
• Low blood sugar (hypoglycemia) when taken with certain diabetes medications
• Kidney damage
• Severe stomach side effects
• Severe allergic reactions
• Gallbladder problems
• Lung problems during anesthesia or deep sedation