Key takeaways
Dexmethylphenidate (Focalin, Focalin XR) and Atomoxetine (Strattera) are both used to treat attention-deficit hyperactivity disorder (ADHD), but they have some key differences. Dexmethylphenidate is a stimulant that works by increasing levels of norepinephrine and dopamine in the brain, while Atomoxetine is a selective norepinephrine reuptake inhibitor (NRI) that raises norepinephrine levels. Dexmethylphenidate is a controlled substance with a risk of misuse and dependence, whereas Atomoxetine is not a controlled substance and doesn't carry the same risk. Dexmethylphenidate is available in both immediate-release and extended-release forms, while Atomoxetine is only available as capsules that you take once or twice daily. Dexmethylphenidate can start working within 30 to 45 minutes, but Atomoxetine may take a week or longer to show effects. Both medications can cause side effects like stomach pain, trouble sleeping, heart problems, and changes in behavior. Atomoxetine also has a risk of suicidal thoughts, especially in children and teens.
