Key takeaways
Cymbalta (duloxetine) and Viibryd (vilazodone) are both medications used to treat major depressive disorder, but they belong to different drug classes and have some key differences. Cymbalta is an SNRI (serotonin and norepinephrine reuptake inhibitor) that also treats anxiety, diabetic neuropathy, fibromyalgia, and long-term pain. Viibryd, on the other hand, is an SSRI and a serotonin (5HT1A) receptor partial agonist, and it is only approved for depression. Cymbalta can be taken with or without food, while Viibryd must be taken with food to ensure proper absorption. Both medications are available as lower-cost generics. Common side effects of Cymbalta include nausea, headache, and dry mouth, while Viibryd often causes diarrhea, nausea, and headache. Additionally, Viibryd is less likely to cause weight gain and sexual side effects compared to other antidepressants, including Cymbalta. Both medications require a gradual dose reduction to avoid withdrawal symptoms if you need to stop taking them.
