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Compare Combipatch vs. Climara Pro

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

CombiPatch (estradiol/norethindrone) and Climara Pro (estradiol/levonorgestrel) are both hormone replacement therapies used to treat menopausal symptoms like hot flashes and night sweats. CombiPatch also helps with vaginal dryness and irritation, while Climara Pro is approved for preventing osteoporosis. CombiPatch needs to be changed twice a week, whereas Climara Pro is changed once a week, making Climara Pro more convenient. Both CombiPatch and Climara Pro are only available as brand names, which can make them expensive. Both medications carry risks of blood clots, heart attacks, and strokes, but CombiPatch has a slightly higher risk of breast pain and menstrual cramps. Additionally, CombiPatch can be used in certain women who haven't gone through menopause yet, unlike Climara Pro, which is only for postmenopausal women.

  • Combipatch (estradiol / norethindrone)
    Climara pro (estradiol / levonorgestrel)
  • Combipatch (estradiol / norethindrone)
    Climara pro (estradiol / levonorgestrel)

  • Summary of Combipatch vs. Climara Pro

    Summary for Estrogen / Progestin
    Prescription only

    CombiPatch (estradiol / norethindrone) is a type of hormone replacement therapy. It treats symptoms of menopause, such as hot flashes, night sweats, and vaginal dryness. This combination medication also restores estrogen levels in people with medical conditions that cause low estrogen. It's a patch that's applied onto the skin twice a week. Common side effects include headache and breast pain.

    Summary for Estrogen replacement / Progestin
    Prescription only

    Climara Pro is a patch that's applied to the skin once a week. It's approved to prevent osteoporosis in people who've gone through menopause. This medication can also treat symptoms like hot flashes and night sweats from menopause. The patch is a hormone replacement therapy; it contains the hormones estradiol and levonorgestrel. Side effects include irregular vaginal bleeding or spotting, breast pain, and skin irritation where the patch is applied.

  • Indications of Combipatch vs. Climara Pro

    Indications for

    In people who have a healthy uterus:

    •Moderate-to-severe symptoms of menopause, like hot flashes, night sweats, vaginal dryness, and vaginal irritation
    •Low estrogen levels caused by certain health conditions (e.g., ovaries aren't working as they should)
    Indications for
    •Treatment of moderate-to-severe symptoms of menopause (e.g., hot flashes, night sweats) for people with a healthy uterus
    •Prevention of osteoporosis for people who've gone through menopause with a healthy uterus

  • Pros and Cons of Combipatch vs. Climara Pro

    Pros and Const for Estrogen / Progestin
    Pros
    •Can help relieve both hot flashes and vaginal dryness
    •Approved for both people who have and haven't gone through menopause (under certain situations)
    •Available as a patch that's applied onto the skin; an alternative to pills or vaginal creams
    •Might have fewer side effects than pills
    Cons
    •Must change the patch twice a week
    •Can fall off if the patch gets wet and rubs against something
    •Chance for irregular vaginal bleeding or withdrawal bleeding
    •No lower-cost generic available; brand name only
    Pros and Const for Estrogen replacement / Progestin
    Pros
    •Comes as a patch, so it might be a good option for people who have trouble swallowing pills
    •Applied once every week
    •Might have fewer side effects than estrogen pills
    Cons
    •Can fall off if it gets too wet
    •No lower-cost generic available; brand name only
    •Not a first-choice option for preventing osteoporosis for people who've gone through menopause

  • Common Side Effects of Combipatch vs. Climara Pro

    Common Side Effects for
    •Breast pain (25-31%)
    •Menstrual cramps (20-21%)
    •Headache (18-20%)
    •Vaginitis (e.g., vaginal pain, itching, burning, or discharge; 6-13%)
    •Weakness (8-12%)
    •Breathing problems (7-12%)
    •Irregular vaginal bleeding or other related menstrual issues (6-12%)
    •Back pain (9-11%)
    •Nausea (8-11%)
    •Sore throat (4-10%)
    Common Side Effects for
    •Application site reaction (e.g., skin irritation; 41%)
    •Vaginal bleeding or spotting (37%)
    •Breast pain (19%)
    •Upper respiratory infection (13%)
    •Depression (6%)
    •Back pain (6%)
    •General pain (5%)
    •Headache (5%)
    •Flu-like symptoms (5%)

  • Warnings of Combipatch vs. Climara Pro

    Common Side Effects for
    •Risk for blood clots and other complications
    •Risk for breast cancer
    •Risk for uterine cancer (also called endometrial cancer)
    •Risk for ovarian cancer
    •Risk for dementia
    •Gallbladder or liver problems in certain people
    •Buildup of fluids in your body (fluid retention)
    •High triglyceride (fat) levels
    •Low thyroid hormone levels
    •Changes in calcium levels in certain people
    Common Side Effects for
    •Blood clots and related complications (e.g., heart attacks, strokes)
    •Breast cancer
    •Uterine or endometrial cancer
    •Ovarian cancer
    •Risk for dementia
    •Gallbladder problems and jaundice
    •Changes in calcium levels in the blood
    •Changes in vision
    •High triglyceride (fat) levels
    •Low thyroid hormone levels in people who take thyroid hormone replacement therapy
    •Buildup of fluids in your body (fluid retention)

  • Prices with our coupons for Combipatch vs. Climara Pro

    Learn more about Combipatch
    Learn more about Climara pro

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