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Clomiphene vs. Anastrozole

Clomid (clomiphene) is a selective estrogen receptor modulator (SERM) used to treat infertility in people wanting to become pregnant. It works by causing ovulation, or egg release. You'll take a dose by mouth every day for 5 days, typically during your menstrual period. Some of the more common side effects include hot flashes, bloating, and stomach pain.

• Female infertility

• Swollen ovaries (14%)
• Hot flashes (10%)
• Stomach pain, discomfort, or bloating (6%)

• Vision changes
• Ovarian hyperstimulation syndrome (OHSS)
• Possible risk of harm to unborn baby

Anastrozole (Arimidex) is prescription oral medication used to treat certain types of breast cancer, including both early and advanced or metastatic stages. It's FDA approved only for postmenopausal women, or those who have already gone through menopause. This medication belongs to a class called aromatase inhibitors, which works by lowering estrogen levels in the body. You take one tablet by mouth once a day, with or without food. Common side effects include hot flashes, weakness, and joint pain.

• Early breast cancer (HR+) in postmenopausal women
• Advanced or metastatic breast cancer HR+ or HR unknown in postmenopausal women
• Advanced breast cancer in postmenopausal women whose cancer has worsened after treatment with tamoxifen

Early breast cancer:

• Hot flashes (36%)
• Muscle and joint problems (36%)
• Tiredness (19%)
• Changes in mood (19%)
• Nausea and vomiting (13%)
• Bone fractures (10%)

Advanced or metastatic breast cancer:

• Nausea and vomiting (34%)
• Hot flashes (26%)

Advanced breast cancer that's worsened after tamoxifen treatment:

• Nausea and vomiting (29%)
• Hot flashes (13%)

• Heart disease
• Bone loss
• Rise in cholesterol levels
• Harm to unborn baby