Clomid
(clomiphene)
Get free couponsLeuprolide
(Lupron Depot)
Get free couponsSummary for Clomiphene
Clomid (clomiphene) is a selective estrogen receptor modulator (SERM) used to treat infertility in people wanting to become pregnant. It works by causing ovulation, or egg release. You'll take a dose by mouth every day for 5 days, typically during your menstrual period. Some of the more common side effects include hot flashes, bloating, and stomach pain.
Indications for Clomiphene
Pros and Cons for Clomiphene
Pros
- Works well for people with polycystic ovary syndrome (PCOS)
- Usually only taken for 5 days during each cycle
- Available as a tablet, unlike many alternatives
Cons
- Typically only recommended for up to 3 cycles, not a long-term treatment
- Can cause vision problems in some rare cases
- Not safe if you have liver problems or certain thyroid problems
Common Side Effects for Clomiphene
- Swollen ovaries (14%)
- Hot flashes (10%)
- Stomach pain, discomfort, or bloating (6%)
Warnings for Clomiphene
- Vision changes
- Ovarian hyperstimulation syndrome (OHSS)
- Possible risk of harm to unborn baby
Summary for Leuprolide
Leuprolide (Lupron Depot) is an injection that treats endometriosis and uterine fibroids (growths in the womb that are typically noncancerous). It's available in two different strengths to allow for a dosing schedule that's either once a month or once every 3 months. This medication is typically given by a healthcare provider. Common side effects of leuprolide (Lupron Depot) include hot flashes and headaches. It's available as brand name only.
Indications for Leuprolide
- Endometriosis
- Before fibroid surgery to help improve anemia due to bleeding from uterine fibroids
Pros and Cons for Leuprolide
Pros
- Only need to get injections monthly or every 3 months, depending on the dose
- Works well to shrink uterine fibroids and reduce bleeding before surgery
- Works well to relieve pain from endometriosis
- Can use together with norethindrone acetate (Aygestin) for endometriosis
Cons
- Available as brand name only
- Injections might be uncomfortable
- Many possible side effects (most commonly, hot flashes or sweats)
- Not safe to use during pregnancy
Common Side Effects for Leuprolide
Side effects for the 3.75 mg dose of leuprolide (Lupron Depot) when used by itself are listed below.
Endometriosis
- Hot flashes or sweats (84%)
- Headache (32%)
- Vaginal inflammation (28%)
- Depression (22%)
- Pain (19%)
- Weight changes (13%)
- Nausea or vomiting (13%)
- Lower sex drive (11%)
- Dizziness (11%)
- Acne (10%)
- Skin reactions (10%)
Uterine fibroids
- Hot flashes or sweats (73%)
- Headache (26%)
- Vaginal inflammation (11%)
- Depression (11%)
Warnings for Leuprolide
- Weakening of bones
- Harm to unborn babies
- Allergic reaction
- Convulsions (seizures)
- Depression
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