Clomid
(clomiphene)
Get free couponsTamoxifen
(Nolvadex)
Get free couponsSummary for Clomiphene
Clomid (clomiphene) is a selective estrogen receptor modulator (SERM) used to treat infertility in people wanting to become pregnant. It works by causing ovulation, or egg release. You'll take a dose by mouth every day for 5 days, typically during your menstrual period. Some of the more common side effects include hot flashes, bloating, and stomach pain.
Indications for Clomiphene
Pros and Cons for Clomiphene
Pros
- Works well for people with polycystic ovary syndrome (PCOS)
- Usually only taken for 5 days during each cycle
- Available as a tablet, unlike many alternatives
Cons
- Typically only recommended for up to 3 cycles, not a long-term treatment
- Can cause vision problems in some rare cases
- Not safe if you have liver problems or certain thyroid problems
Common Side Effects for Clomiphene
- Swollen ovaries (14%)
- Hot flashes (10%)
- Stomach pain, discomfort, or bloating (6%)
Warnings for Clomiphene
- Vision changes
- Ovarian hyperstimulation syndrome (OHSS)
- Possible risk of harm to unborn baby
Summary for Tamoxifen
Tamoxifen (Nolvadex) is a selective estrogen receptor modulator (SERM). It’s used to treat early stage and advanced or metastatic hormone receptor-positive (HR+) breast cancer in males and females. It’s also used to lower the risk for breast cancer in females who have a higher risk for breast cancer. Tamoxifen (Nolvadex) is an oral tablet that's taken by mouth, usually once a day. Common side effects of this medication include hot flashes, vaginal discharge, and swelling in the arms and legs, which might lead to weight gain. Brand name Nolvadex is no longer available.
Indications for Tamoxifen
- Metastatic HR+ breast cancer
- Early-stage HR+ breast cancer after surgery to lower the risk of breast cancer coming back
- Ductal carcinoma in situ (DCIS) in females after breast surgery and radiation to lower the risk of breast cancer coming back
- Lowering the risk of breast cancer in females who are considered high risk
Pros and Cons for Tamoxifen
Pros
- Usually taken once a day
- Oral tablet is available as a lower-cost generic
- Might help prevent bone loss (osteoporosis) after menopause
Cons
- Might raise your risk for blood clots, uterine cancer, and cataracts
- Can’t take while pregnant or breastfeeding
- Usually taken long term (at least 5 years)
Common Side Effects for Tamoxifen
- Hot flashes (up to 80%)
- Vaginal discharge (up to 55%)
- Swelling in the arms and legs (up to 32%)
- Nausea (up to 26%)
- Irregular or no monthly bleeding (up to 25%)
- Vaginal bleeding (up to 23%)
- Weight loss (23%)
- Skin changes (19%)
Warnings for Tamoxifen
- Blood clots
- Changes in the uterus and risk of uterine cancer
- Eye problems
- Liver problems
- High calcium levels in the blood
- Low platelet count (risk of bleeding)
- Harm to unborn baby
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