Clomid
(clomiphene)
Get free couponsLetrozole
(Femara)
Get free couponsSummary for Clomiphene
Clomid (clomiphene) is a selective estrogen receptor modulator (SERM) used to treat infertility in people wanting to become pregnant. It works by causing ovulation, or egg release. You'll take a dose by mouth every day for 5 days, typically during your menstrual period. Some of the more common side effects include hot flashes, bloating, and stomach pain.
Indications for Clomiphene
Pros and Cons for Clomiphene
Pros
- Works well for people with polycystic ovary syndrome (PCOS)
- Usually only taken for 5 days during each cycle
- Available as a tablet, unlike many alternatives
Cons
- Typically only recommended for up to 3 cycles, not a long-term treatment
- Can cause vision problems in some rare cases
- Not safe if you have liver problems or certain thyroid problems
Common Side Effects for Clomiphene
- Swollen ovaries (14%)
- Hot flashes (10%)
- Stomach pain, discomfort, or bloating (6%)
Warnings for Clomiphene
- Vision changes
- Ovarian hyperstimulation syndrome (OHSS)
- Possible risk of harm to unborn baby
Summary for Letrozole
Letrozole (Femara) is an aromatase inhibitor, a type of hormonal therapy. It’s FDA-approved to treat or prevent breast cancer in females who’ve already gone through menopause. It’s sometimes prescribed off-label by fertility specialists to help females become pregnant. Letrozole (Femara) is taken by mouth, typically once a day for breast cancer. Common side effects include hot flashes and pain in the bones, muscles, and joints.
Indications for Letrozole
- Breast cancer in females who have already gone through menopause:
- Preventing breast cancer from coming back (hormone receptor-positive early breast cancer), sometimes after treatment with tamoxifen (Nolvadex)
- Treatment of advanced or metastatic breast cancer
Pros and Cons for Letrozole
Pros
- Can be used during early and advanced stages of breast cancer
- Taken by mouth once daily
- Available as a lower-cost generic
Cons
- Only for females who've reached menopause (for treating breast cancer)
- Can cause menopausal symptoms, such as hot flashes and night sweats
- Can weaken your bones if taken long-term
Common Side Effects for Letrozole
- High blood cholesterol levels (52%)
- Hot flashes (34%)
- Muscle, bone, or joint pain (25%)
Note: Side effects reported by females who took letrozole (Femara) after surgery for early breast cancer.
Warnings for Letrozole
- Weakened bones
- High cholesterol levels
- Liver problems
- Risk of drowsiness
- Harm to unborn baby
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