Key takeaways
Ibandronate (Boniva) and Prolia (denosumab) are both used to treat osteoporosis, but they work in different ways and have different dosing schedules. Ibandronate (Boniva) is a bisphosphonate that you take as a tablet once a month or as an IV infusion every three months. It is only approved for postmenopausal women. Prolia (denosumab), on the other hand, is a monoclonal antibody given as an injection every six months and is approved for both men and women, as well as for those with osteoporosis caused by certain medications. While both medications help strengthen bones, Prolia (denosumab) requires you to take calcium and vitamin D supplements daily to prevent low calcium levels, which can be dangerous. Ibandronate (Boniva) can cause stomach and esophagus irritation, so you need to follow specific instructions when taking it. Prolia (denosumab) can cause serious infections and jawbone problems, especially if you have dental issues or a weakened immune system.
