Aveed vs. Jatenzo for Testosterone Replacement: Important Differences and Potential Risks.

Aveed

(testosterone undecanoate)

Jatenzo

(testosterone undecanoate)

Summary for Aveed

Prescription only

Aveed (testosterone undecanoate) is an injectable testosterone that’s used to treat low testosterone in adult males. It's an FDA-approved testosterone replacement therapy that must be injected by a healthcare professional due to possible allergic reactions and a serious warning called pulmonary oil microembolism (POME), which causes symptoms such as coughing, chest pain, and trouble breathing. Initially, you'll receive the first two injections a month apart, then an injection every 10 weeks after that. Common side effects include acne, pain at the injection site, and fatigue.

Indications for Aveed

Low testosterone (also called hypogonadism)

Pros and Cons for Aveed

Pros

Works well to replace testosterone in your body
Can be given every 10 weeks (after the first 2 injections)
No accidental testosterone exposure to another person through skin-to-skin contact like testosterone gels

Cons

Only available through a REMS program because of life-threatening side effects
Must be injected by your prescriber, so it can't be given at home
Only available as a brand-name medication

Common Side Effects for Aveed

Acne (5%)
Injection site pain (5%)
Rise in prostate-specific antigen (PSA, 5%)
Rise in estrogen levels (3%)
Tiredness (2%)
Irritability (2%)
Trouble sleeping (insomnia, 2%)
Mood swings (2%)

Warnings for Aveed

Pulmonary oil microembolism (POME) and severe allergic reactions
Prostate problems
Risk of blood clots, including heart attack or stroke
Potential for misuse, dependency, and addiction
Liver problems
Swelling in the legs or arms (edema)
Sleep apnea
High calcium in the blood

Summary for Jatenzo

Prescription only

Jatenzo (testosterone undecanoate) is an oral capsule used for testosterone replacement therapy (TRT) in adult males with hypogonadism, a condition that causes low testosterone production. You take a dose by mouth twice a day, once in the morning and once in the evening. Common side effects include headaches, high blood pressure, and nausea. This medication is only available as a brand-name medication, meaning there are no generic versions.

Indications for Jatenzo

Low testosterone (hypogonadism)

Pros and Cons for Jatenzo

Pros

Works well to replace testosterone in the body
Comes as a capsule taken by mouth
Lower risk of liver problems compared to other testosterone products

Cons

Must take it twice a day
Can cause high blood pressure, which can raise your risk of serious heart problems
Requires regular blood tests to monitor testosterone and nutrient levels