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Amerge vs. Cafergot

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Naratriptan and ergotamine/caffeine (Migergot) are both used to treat migraines, but they work differently and have distinct features. Naratriptan, available as a generic, is a triptan that you take as a tablet when you feel a migraine coming on. It works by tightening blood vessels in the brain and reducing swelling. You can take a second dose if needed, but no more than 5 mg in a day. Common side effects include nausea, sleepiness, and dizziness. On the other hand, ergotamine/caffeine, also available as a generic, combines an ergot derivative with caffeine and is used for both migraines and cluster headaches. It comes in tablet and suppository forms. You take it at the first sign of a headache, but you must limit your doses to avoid serious side effects like vomiting and numbness. Ergotamine/caffeine can cause nausea, heart-related chest pain, and high blood pressure. Naratriptan and ergotamine/caffeine should be avoided during pregnancy.

Naratriptan

 

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Cafergot

(ergotamine / caffeine)

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Summary for Amerge

Prescription only

Naratriptan is a triptan that's used to treat migraines with or without aura in adults. While the brand name Amerge is no longer available, there's a generic version that you can get by prescription. Naratriptan is a tablet that's swallowed whole once, typically as a single dose. But you can take the medication again 4 hours later if the first dose didn't work to relieve your migraine. Side effects aren't common, but it might make you nauseous, sleepy, or dizzy.

Indications for Amerge

Pros and Cons for Amerge

Pros

Cons

  • Only available as a tablet, so it might not be a good option for people who have trouble swallowing pills during migraine attacks
  • Can take up to 4 hours to get the maximum benefit
  • Hasn't been studied in children
  • Can't use to prevent migraines

Common Side Effects for Amerge

  • Nausea (up to 5%)

Warnings for Amerge

  • Heart problems and high blood pressure
  • Stroke or other brain injury
  • Extreme narrowing of blood vessels
  • Worsened headaches if naratriptan is taken too often
  • Serotonin syndrome

Summary for Cafergot

Prescription only

Cafergot (ergotamine / caffeine) is used to treat cluster headaches and migraines in adults. It's available as a tablet that's taken by mouth, as well as a suppository that's inserted into the rectum. Typically, you take a dose as soon as you feel a headache coming on. But there's a limit to how many doses you can take each week because taking this medication too often can lead to serious side effects, such as vomiting and numbness. Brand name Cafergot is discontinued.

Indications for Cafergot

Pros and Cons for Cafergot

Pros

  • Suppository is a good option for people who've trouble swallowing pills
  • Tablet is available as a lower-cost generic
  • Can start to feel relief after a half hour (for the tablets) or an hour (for the suppository); and you may take an additional dose if no relief

Cons

  • Not for daily or long-term use
  • Can't take while pregnant
  • Not safe for use for people with kidney or liver problems
  • Rectal suppository is brand name only and requires refrigeration

Common Side Effects for Cafergot

  • Nausea

Warnings for Cafergot

  • Dangerously low blood flow to your brain and limbs
  • Fibrosis (scarring)
  • Allergic reaction to yellow dye

Prices with our coupons for Amerge vs. Cafergot

Price Card Drug Icon
Naratriptan1 dose pack / 9 tablets of 2.5mg
$23.30$110.44
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Price Card Drug Icon
Ergotamine/Caffeine30 tablets / 1mg/100mg
$112.30$478.73
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