Key takeaways
Naratriptan and ergotamine/caffeine (Migergot) are both used to treat migraines, but they work differently and have distinct features. Naratriptan, available as a generic, is a triptan that you take as a tablet when you feel a migraine coming on. It works by tightening blood vessels in the brain and reducing swelling. You can take a second dose if needed, but no more than 5 mg in a day. Common side effects include nausea, sleepiness, and dizziness. On the other hand, ergotamine/caffeine, also available as a generic, combines an ergot derivative with caffeine and is used for both migraines and cluster headaches. It comes in tablet and suppository forms. You take it at the first sign of a headache, but you must limit your doses to avoid serious side effects like vomiting and numbness. Ergotamine/caffeine can cause nausea, heart-related chest pain, and high blood pressure. Naratriptan and ergotamine/caffeine should be avoided during pregnancy.
