Key takeaways
Naratriptan (Amerge) and ergotamine/caffeine (Cafergot, Migergot) are both medications used to treat migraines, but they belong to different medication classes. Naratriptan is a triptan, while ergotamine/caffeine is an ergot derivative combined with caffeine. Naratriptan is available as an oral tablet, whereas ergotamine/caffeine can be taken as an oral tablet or a rectal suppository. Naratriptan is typically taken as a single dose, with the option to take another dose 4 hours later if needed, but you shouldn't exceed 5 mg in a day. Ergotamine/caffeine is taken as soon as you feel a headache coming on, with a limit of 6 tablets per headache episode or 10 tablets per week. Both medications are available as a lower-cost generic. Common side effects of naratriptan include nausea and dizziness, while ergotamine/caffeine can cause nausea, vomiting, and numbness. Naratriptan can interact with antidepressants, while ergotamine/caffeine should not be taken with certain antibiotics or protease inhibitors.
