Bupropion (Zyban) Side Effects
What should I watch for?
Visit your doctor or health care professional for regular checks on your progress. This medicine should be used together with a patient support program. It is important to participate in a behavioral program, counseling, or other support program that is recommended by your health care professional.
Patients and their families should watch out for new or worsening thoughts of suicide or depression. Also watch out for sudden changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of treatment or after a change in dose, call your health care professional.
Avoid alcoholic drinks while taking this medicine. Drinking excessive alcoholic beverages, using sleeping or anxiety medicines, or quickly stopping the use of these agents while taking this medicine may increase your risk for a seizure.
Do not drive or use heavy machinery until you know how this medicine affects you. This medicine can impair your ability to perform these tasks.
Do not take this medicine close to bedtime. It may prevent you from sleeping.
Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.
Do not use nicotine patches or chewing gum without the advice of your doctor or health care professional while taking this medicine. You may need to have your blood pressure taken regularly if your doctor recommends that you use both nicotine and this medicine together.
Side Effects to watch for
Side effects that you should report to your doctor or health care professional as soon as possible:
- allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
- breathing problems
- changes in vision
- elevated mood, decreased need for sleep, racing thoughts, impulsive behavior
- fast or irregular heartbeat
- hallucinations, loss of contact with reality
- increased blood pressure
- redness, blistering, peeling or loosening of the skin, including inside the mouth
- suicidal thoughts or other mood changes
- unusually weak or tired
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
What may interact with this drug?
Do not take this medicine with any of the following medications:
- MAOIs like Azilect, Carbex, Eldepryl, Marplan, Nardil, and Parnate
- methylene blue (injected into a vein)
- other medicines that contain bupropion like Wellbutrin
This medicine may also interact with the following medications:
- certain medicines for anxiety or sleep
- certain medicines for blood pressure like metoprolol, propranolol
- certain medicines for depression or psychotic disturbances
- certain medicines for HIV or AIDS like efavirenz, lopinavir, nelfinavir, ritonavir
- certain medicines for irregular heart beat like propafenone, flecainide
- certain medicines for Parkinson's disease like amantadine, levodopa
- certain medicines for seizures like carbamazepine, phenytoin, phenobarbital
- steroid medicines like prednisone or cortisone
- stimulant medicines for attention disorders, weight loss, or to stay awake