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Sertraline

Sertraline (Zoloft) is an inexpensive drug used to treat depression. It may also be used to treat obsessive compulsive disorder, panic disorder, post-trauma stress, premenstrual dysphoric disorder (PMDD), or social anxiety. This drug is more popular than comparable drugs. It is available in brand and generic form. Generic sertraline is is covered by most Medicare and insurance plans, but some pharmacy coupons or cash prices may be lower. Compare SSRIs.
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Zoloft Side Effects

What should I watch for?

Tell your doctor if your symptoms do not get better or if they get worse. Visit your doctor or health care professional for regular checks on your progress. Because it may take several weeks to see the full effects of this medicine, it is important to continue your treatment as prescribed by your doctor.

Patients and their families should watch out for new or worsening thoughts of suicide or depression. Also watch out for sudden changes in feelings such as feeling anxious, agitated, panicky, irritable, hostile, aggressive, impulsive, severely restless, overly excited and hyperactive, or not being able to sleep. If this happens, especially at the beginning of treatment or after a change in dose, call your health care professional.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

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Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Decreased sexual desire or ability

failure to discharge semen (in men)

Less common or rare

Aggressive reaction

breast tenderness or enlargement

confusion

convulsions

diarrhea

drowsiness

dryness of the mouth

fast talking and excited feelings or actions that are out of control

fever

inability to sit still

increase in body movements

increased sweating

increased thirst

lack of energy

loss of bladder control

mood or behavior changes

muscle spasm or jerking of all extremities

nosebleeds

overactive reflexes

racing heartbeat

red or purple spots on the skin

restlessness

shivering

skin rash, hives, or itching

sudden loss of consciousness

unusual or sudden body or facial movements or postures

unusual secretion of milk (in females)

Incidence not known

Abdominal or stomach pain

bleeding gums

blindness

blistering, peeling, or loosening of the skin

bloating

blood in the urine

bloody, black, or tarry stools

blue-yellow color blindness

blurred vision

chest pain or discomfort

chills

clay-colored stools

cough or hoarseness

darkened urine

decreased urine output

decreased vision

depressed mood

difficulty with breathing

difficulty with speaking

difficulty with swallowing

drooling

dry skin and hair

eye pain

fainting

feeling cold

feeling of discomfort

feeling, seeing, or hearing things that are not there

general feeling of discomfort, illness, tiredness, or weakness

hair loss

high fever

high or low blood pressure

hoarseness or husky voice

hostility

increased clotting times

indigestion

inflamed joints

irritability

joint or muscle pain

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

lethargy

lightheadedness

loss of appetite

loss of balance control

loss of bladder control

lower back or side pain

muscle aches

muscle cramps and stiffness

muscle trembling, jerking, or stiffness

muscle twitching

painful or difficult urination

pains in the stomach, side, or abdomen, possibly radiating to the back

pale skin

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

rapid weight gain

rash

red, irritated eyes

red, sore, or itching skin

right upper stomach pain and fullness

severe mood or mental changes

severe muscle stiffness

shuffling walk

sore throat

sores, ulcers, or white spots in the mouth or on the lips

sores, welting, or blisters

stiffness of the limbs

sweating

swelling of the face, ankles, or hands

swollen or painful glands

talking or acting with excitement you cannot control

tightness in the chest

troubled breathing

twisting movements of the body

twitching

uncontrolled movements, especially of the face, neck, and back

unexplained bleeding or bruising

unpleasant breath odor

unusual behavior

unusual tiredness or weakness

vomiting of blood

weight gain

yellow eyes and skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Acid or sour stomach

belching

decreased appetite or weight loss

diarrhea or loose stools

heartburn

sleepiness or unusual drowsiness

stomach or abdominal cramps, gas, or pain

trouble sleeping

Less common

Agitation, anxiety, or nervousness

bladder pain

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

changes in vision

cloudy urine

constipation

difficult, burning, or painful urination

flushing or redness of the skin, with feeling of warmth or heat

frequent urge to urinate

increased appetite

pain or tenderness around the eyes and cheekbones

stuffy or runny nose

Incidence not known

Flushed, dry skin

fruit-like breath odor

increased hunger

increased urination

redness or other discoloration of the skin

severe sunburn

swelling of the breasts (in women)

unexplained weight loss

unusual secretion of milk (in women)

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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