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Trintellix

vortioxetine
Used for Depression
Used for Depression

Trintellix, the brand name for vortioxetine, belongs to a drug class called atypical antidepressants. It's used to treat depression in adults. This medication comes as a tablet that you take by mouth once a day. Common side effects include nausea, diarrhea, and dry mouth. Sexual side effects can also happen, but it's usually less likely than with some other antidepressants. As of 2025, there's no generic version of Trintellix (vortioxetine) available yet.

Reviewed by:
reviewer
Kristianne Hannemann, PharmD
reviewer
Cydnee Ng, PharmD
Last reviewed on July 21, 2025
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Trintellix (vortioxetine)?

What is Trintellix (vortioxetine) used for?

How Trintellix (vortioxetine) works

Trintellix (vortioxetine) is an atypical antidepressant. It's not fully understood how the medication works. But researchers think it helps boost serotonin in your brain. Serotonin is a chemical in the brain that plays a role in regulating mood and emotion.

When does Trintellix (vortioxetine) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsTrintellix
Drug ClassAtypical antidepressant
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the side effects of Trintellix (vortioxetine)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Nausea (21-32%)
  • Diarrhea (7-10%)
  • Dizziness (6-9%)
  • Dry mouth (6-8%)
  • Vomiting (3-6%)
  • Constipation (3-6%)

Other Side Effects

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Suicidal thoughts and behavior
  • Serotonin syndrome: fast heart rate, sweating, muscle stiffness or spasms, fever, confusion
  • Very low sodium: nausea, vomiting, headache, memory problems, confusion, muscle weakness or cramps, low blood pressure
  • Serious bleeding: dizziness, pale skin, feeling weak, getting nosebleeds often, bleeding that's hard to stop, bruising that won't go away, vomiting blood, black and tarry stool
When do Trintellix (vortioxetine) possible side effects begin and end?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Nausea or vomiting
Dizziness
Dry mouth
Diarrhea
Risk of suicidal thoughts
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

More on Trintellix (vortioxetine) side effects

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Trintellix: woman holding a pill and glass of water 2166843137

Does Trintellix Cause Weight Gain?

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The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Incidence not known

Agitation

blood in the stool or urine

confusion

cough

decreased urine output

diarrhea

difficulty swallowing

dizziness

fast or irregular heartbeat

fever

headache

hives, itching

hostility

increased sweating

increased thirst

irritability

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs

muscle pain or cramps

nausea or vomiting

nose bleeds

overactive reflexes

poor coordination

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

red or purple spots on the skin

restlessness

seizures

shivering

sweating

swelling of the breasts or unusual milk production

swelling of the face, ankles, or hands

talking or acting with excitement you cannot control

tightness in the chest

trembling or shaking

trouble breathing

twitching

unusual bleeding or bruising

unusual tiredness or weakness

vomiting blood

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Difficulty having a bowel movement (stool)

dry mouth

Less common

Abnormal ejaculation

bloated or full feeling

decreased sexual performance or desire

excess air or gas in the stomach or intestines

itching skin

passing gas

unusual dreams

Incidence not known

Acid or sour stomach

belching

blurred vision

change in taste

dizziness or lightheadedness

eye pain

feeling of constant movement of self or surroundings

feeling of warmth

heartburn

indigestion

loss of taste

redness of the face, neck, arms, and occasionally, upper chest

sensation of spinning

stomach discomfort, upset, or pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Trintellix (vortioxetine)

thumbs-up

Pros

Only taken once a day

Can start to improve depression in as early as 2 weeks

Less likely to cause weight gain than other antidepressants

thumbs-down

Cons

Can take up to a month or more before you feel the full effects

Not approved for use in children

Not approved to treat anxiety

pharmacist-tips

Pharmacist tips for Trintellix (vortioxetine)

pharmacist

  • You can take Trintellix (vortioxetine) with or without food. Food won't affect how well it works for you.

    • Set an alarm to help you remember to take Trintellix (vortioxetine) at the same time every day.

      • You should swallow the Trintellix (vortioxetine) tablet whole. It usually isn't a good idea to cut it in half. The tablets aren't scored, so cutting them can give you uneven halves and make you take the wrong dose. Talk to your prescriber if you want to take a lower dose of Trintellix (vortioxetine).

        • Nausea is a common side effect of Trintellix (vortioxetine) during the first week you take it. Most times, you should feel better over the next few weeks. If the nausea doesn't go away, tell your prescriber so they can help you manage this side effect.

          • It's best to avoid drinking alcohol while taking Trintellix (vortioxetine). It can make side effects like dizziness and nausea worse. Talk to a healthcare professional if you have questions about whether it's safe to drink while taking an antidepressant.

            • Don't stop taking Trintellix (vortioxetine) suddenly. Otherwise, it can cause withdrawal symptoms, like dizziness, anxiety, headache, and trouble sleeping. Talk to your prescriber if you want to stop the medication. They can lower the dose slowly over time before you stop completely. This helps lower your risk of withdrawal.

              • Trintellix (vortioxetine) used to have a different brand name, Brintellix. The manufacturer changed its brand name because it sounded too much like the blood thinner Brilinta (ticagrelor). The name change helped lower the risk of getting the two medications mixed up.

                faqs

                Frequently asked questions about Trintellix (vortioxetine)

                Is Trintellix (vortioxetine) an SSRI?
                No, Trintellix (vortioxetine) isn't called a selective serotonin reuptake inhibitor (SSRI). Instead, it's called an atypical antidepressant. But they work in similar ways. Like SSRIs, Trintellix (vortioxetine) is thought to raise serotonin levels in the brain. This helps make your mood better.
                Does Trintellix (vortioxetine) cause weight gain?
                Trintellix (vortioxetine) doesn't usually cause weight gain. In fact, it's considered a "weight-neutral" antidepressant. In studies, people had minimal changes in weight after a year of taking the medication. In general, you can help manage your weight by making some healthy choices. Try to eat a nutritious, balanced diet and exercise for at least 30 minutes a day. If you're worried about your weight, talk to a healthcare professional.
                How long does it take for Trintellix (vortioxetine) to work?
                Some people might start to feel their mood get better within 2 weeks of taking Trintellix (vortioxetine). But it could take a month of treatment or longer to feel the full effects of this medication. If you don't feel any better after that time, talk to your prescriber. They might decide to give you a higher dose of Trintellix (vortioxetine), if possible. They can also talk with you about other options.
                Is Trintellix (vortioxetine) a controlled substance?
                No, Trintellix (vortioxetine) isn't a controlled substance. The medication isn't known to have a risk of dependence.
                Is there a generic for Trintellix (vortioxetine)?
                No. As of 2025, Trintellix (vortioxetine) is only available as a brand-name medication. This could change in 2026 when the medication's patent is set to expire. This would let generic manufacturers make a generic version of the medication.
                Can Trintellix (vortioxetine) help anxiety?
                Trintellix (vortioxetine) isn't approved by the FDA to treat anxiety. But some studies have looked into using the medication for this purpose. This is considered an "off-label" use of the medication. In general, we need more studies to really know if it helps and if it's safe for anxiety. Talk to a healthcare professional about how to handle your anxiety.
                Can Trintellix (vortioxetine) cause withdrawal?
                You could have withdrawal symptoms if you stop taking Trintellix (vortioxetine) too suddenly. You might get headaches, feel like you have the flu, feel anxious, and have trouble sleeping. If you want to stop taking Trintellix (vortioxetine), talk to your prescriber first. They can help you stop safely by lowering your dose a little at a time. This helps you avoid getting withdrawal symptoms.
                What's the difference between Trintellix and Lexapro?
                Trintellix (vortioxetine) and escitalopram (Lexapro) are both medications for depression that you take once a day. They work in similar ways by raising the serotonin levels in your brain to help with mood. But they're actually two different types of antidepressants. Trintellix is only approved for adults. But Lexapro can be used in both adults and children of certain ages. Plus, Lexapro is also approved to help people with anxiety. Ask your prescriber to compare these medications and see which one is right for you.
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                What are the risks and warnings for Trintellix (vortioxetine)?

                Trintellix (vortioxetine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                risk-warning

                Suicidal thoughts or behavior

                • Risk factors: Age 24 years or younger | First starting Trintellix (vortioxetine) or when the dose changes

                  Trintellix (vortioxetine) may increase your risk of suicidal thoughts or behavior, especially in people under the age of 25. Watch out for worsening depression or any unusual changes in your mood or behavior, especially during the first few months of treatment or with a dose change. Talk to a healthcare professional if you experience any of these symptoms, and seek urgent care if needed.

                  risk-warning

                  Serotonin syndrome

                  • Risk factors: Taking other medications that raise serotonin levels in the brain

                    Trintellix (vortioxetine) can cause a very serious and dangerous problem called serotonin syndrome. This happens when you have too much serotonin in your brain.

                    Your risk is higher if you take Trintellix (vortioxetine) with other medications that also make your serotonin go up. They can include other antidepressants, some opioid pain medications, and triptans for migraine. That's why it's important to tell your care team about all the medications you take. They can check if you're at risk for serotonin syndrome.

                    Stop taking Trintellix (vortioxetine) and get medical help right away if you have signs of serotonin syndrome. Look out for fever, a lot of sweating, fast heart rate, muscle stiffness or spasms, and confusion.

                    risk-warning

                    Higher risk of bleeding

                    • Risk factors: Taking blood thinners or other medications that make bleeding or bruising easier

                      Trintellix (vortioxetine) can raise the risk that you can bleed more easily. The risk is even higher if you also take medications that have a bleeding risk. These include nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen (Advil) and aspirin. It also includes blood thinners like warfarin (Coumadin).

                      Tell your prescriber and pharmacist about your medications while taking Trintellix (vortioxetine). They can check your bleeding risk. Get medical help right away if you have bleeding that's hard to stop, bruising that doesn't go away, vomit blood, or have black and tarry stool. These might be signs of a serious bleed.

                      risk-warning

                      Not for use alone for bipolar disorder

                      • Risk factors: Personal or family history of bipolar disorder, mania, or hypomania

                        Giving someone with bipolar disorder an antidepressant like Trintellix (vortioxetine) by itself can sometimes make them have a manic episode. They can have lots of energy, become very talkative, have racing thoughts, and do risky things. In studies, manic signs were rare with Trintellix (vortioxetine).

                        Before you start Trintellix (vortioxetine), it's important to tell your prescriber if you or someone in your family has bipolar disorder. Your prescriber will also check if you have this problem or if you're at risk of having it. If so, they'll make sure you get the right help.

                        risk-warning

                        Withdrawal symptoms

                        • Risk factors: Stopping Trintellix (vortioxetine) too suddenly

                          Don't stop taking Trintellix (vortioxetine) all of a sudden without talking to your prescriber. Stopping it too quickly could make you have withdrawal symptoms. You could feel nauseous, sweat a lot, feel dizzy, have headaches, and have trouble sleeping.

                          If you want to stop taking Trintellix (vortioxetine), tell your prescriber first. They can help you stop safely by lowering your dose over time before you stop completely.

                          risk-warning

                          Worsening of glaucoma in certain people

                          • Risk factors: History of angle-closure glaucoma

                            Antidepressants such as Trintellix (vortioxetine) can sometimes cause glaucoma to get worse for some people. Tell your prescriber if you have narrow-angle eyes or angle-closure glaucoma and haven't had laser eye surgery.

                            Call your eye specialist right away if you suddenly have blurry vision, severe eye pain, or see rings of light around lights. These could be signs of a serious eye problem called an angle-closure attack.

                            risk-warning

                            Low sodium levels

                            • Risk factors: Older age | Taking diuretic medications

                              Trintellix (vortioxetine) can sometimes make you have low sodium levels in your blood. Watch out for signs like headaches, trouble focusing, feeling confused or weak, or being unsteady on your feet. This can lead to falls. Stop taking this medication and talk to your prescriber right away if this happens. Get urgent care if needed.

                              risk-warning

                              Sexual side effects

                              Trintellix (vortioxetine) might cause problems with sex for both males and females. These problems can include trouble with ejaculation or erectile dysfunction. It can also include not wanting to have sex as much or trouble having an orgasm.

                              If you notice changes in your sex life that worry you while taking Trintellix (vortioxetine), let your prescriber know. They can check if something else is causing these problems and find ways to help you feel better.

                              dosage

                              Trintellix (vortioxetine) dosage forms

                              The average cost for 30 tablets of 10mg of Trintellix (vortioxetine) is $10.00 with a free GoodRx coupon. This is 98.39% off the average retail price of $619.64.
                              tablet
                              Tablet
                              DosageQuantityPrice as low asPrice per unit
                              5mg30 tablets$10.00$0.33
                              10mg30 tablets$10.00$0.33
                              20mg30 tablets$10.00$0.33

                              Typical dosing for Trintellix (vortioxetine)

                              The typical starting dose is 10 mg by mouth once daily. The maximum dose is 20 mg by mouth per day.

                              Your prescriber can adjust the dose based on how well Trintellix (vortioxetine) is working and if you have side effects. They'll also adjust the dose if you take certain interacting medications.

                              More on Trintellix (vortioxetine) dosage forms

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                              interactions

                              Interactions between Trintellix (vortioxetine) and other drugs

                              Trintellix (vortioxetine) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Trintellix (vortioxetine). Please note that only the generic name of each medication is listed below.

                              More on Trintellix (vortioxetine) interactions

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                              Trintellix and Alcohol: Is This A Risky Combination?

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                              Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                              Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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                              contraindications-icon

                              Trintellix (vortioxetine) contraindications

                              Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Trintellix (vortioxetine) will not be safe for you to take.
                              alternatives

                              What are alternatives to Trintellix (vortioxetine)?

                              There are a number of medications that your doctor can prescribe in place of Trintellix (vortioxetine). Compare a few possible alternatives below.
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                              latest news

                              What is the latest news about Trintellix (vortioxetine)?

                              Trintellix is a medication that treats depression in adults. The recommended dosage starts at 10 mg daily. Learn more about Trintellix dosages here.

                              Trintellix Dosages for Adults: Your GoodRx Guide

                              Trintellix is a medication that treats depression in adults. The recommended dosage starts at 10 mg daily. Learn more about Trintellix dosages here.
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                              Trintellix and Alcohol: Is This A Risky Combination?

                              Can you have a few drinks if you take Trintellix? Experts don’t recommend mixing Trintellix and alcohol, if possible. Here’s why.
                              Learn common interactions to know about when taking Trintellix, including medication and supplement interactions.

                              From Bupropion and Tramadol to Warfarin: 5 Trintellix Interactions to Watch For

                              Learn common interactions to know about when taking Trintellix, including medication and supplement interactions.
                              You may experience side effects while taking Trintellix, including sexual side effects and more. Learn about Trintellix side effects and how to deal with them.

                              Nausea, Constipation, and Dizziness: 8 Trintellix Side Effects You Should Know About

                              You may experience side effects while taking Trintellix, including sexual side effects and more. Learn about Trintellix side effects and how to deal with them.
                              In clinical trials, the antidepressant Trintellix (vortioxetine) didn’t cause major weight gain. But some people still report it.

                              Does Trintellix Cause Weight Gain?

                              In clinical trials, the antidepressant Trintellix (vortioxetine) didn’t cause major weight gain. But some people still report it.
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                              images

                              Trintellix (vortioxetine) images

                              Yellow Oval 10 And Tl - Trintellix 10mg Tablet
                              This medicine is Yellow, Oval Tablet Imprinted With "10" And "Tl".Yellow Oval 10 And Tl - Trintellix 10mg Tablet

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                              References

                              Best studies we found

                              Alam, M. Y., et al. (2014). Safety, tolerability, and efficacy of vortioxetine (Lu AA21004) in major depressive disorder: Results of an open-label, flexible-dose, 52-week extension study. International Clinical Psychopharmacology.

                              Hu, X. H., et al. (2004). Incidence and duration of side effects and those rated as bothersome with selective serotonin reuptake inhibitor treatment for depression: Patient reported versus physician estimate. Journal of Clinical Psychiatry.

                              Khazaeni, B., et al. (2023). Acute angle-closure glaucoma. StatPearls.

                              View All References (6)

                              Lundbeck. (2021). U.S. court issues decision in Trintellix patent litigation upholding active ingredient patent.

                              Porter, D. (2020). Narrow angles. American Academy of Ophthalmology.

                              Takeda Pharmaceuticals America, Inc. (2025). Trintellix- vortioxetine tablet, film coated [package insert]. DailyMed.

                              Takeda Pharmaceuticals U.S.A., Inc. (2016). Brintellix (vortioxetine) renamed Trintellix (vortioxetine) in U.S. to avoid name confusion.

                              U.S. Food and Drug Administration. (2018). Suicidality in children and adolescents being treated with antidepressant medications.

                              Yee, A., et al. (2018). Vortioxetine treatment for anxiety disorder: A meta-analysis study. Current Drug Targets.

                              GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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