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Levalbuterol Coupon - Levalbuterol 15g of 45mcg inhaler

levalbuterol

Generic Xopenex HFA
Used for Asthma, COPD

Levalbuterol (brand name Xopenex HFA) is a prescription rescue inhaler used to treat or prevent sudden wheezing or shortness of breath from breathing problems like asthma. It's approved for adults and children 4 years and older. You use it by inhaling 1 to 2 puffs by mouth every 4 to 6 hours as needed. Common side effects include sore throat, dizziness, and a stuffy or runny nose.

Reviewed by:Last reviewed on March 2, 2026
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What is Levalbuterol (Xopenex HFA)?

What is Levalbuterol (Xopenex HFA) used for?

  • Treat or prevent tightening of airways in adults and children 4 years and older with certain breathing problems, such as asthma

How Levalbuterol (Xopenex HFA) works

Levalbuterol (Xopenex HFA) is a short-acting beta-agonist (SABA). It's a rescue inhaler that works quickly to relax the muscles around your airways. This helps open your lungs and makes it easier for you to breathe.

When does Levalbuterol (Xopenex HFA) start working?Time passed since treatment started:
MINUTES
Initial effect
HOURS
Full effect
DAYS
WEEKS
MONTHS

Drug facts

Common BrandsXopenex HFA
Drug ClassSABA
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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Side effects of Levalbuterol (Xopenex HFA)

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

People 12 years and older:

  • Asthma (9%)
  • Sore throat (8%)
  • Stuffy or runny nose (7%)
  • Pain (4%)
  • Dizziness (3%)

Children 4 to 11 years old:

  • Vomiting (11%)
  • Accidental injury (9%)
  • Sore throat (7%)
  • Bronchitis (3%)

Less Common Side Effects

  • Nervousness
  • Tremor
  • Chest pain
  • Cough
  • Hoarseness

Levalbuterol (Xopenex HFA) serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Sudden narrowing of the airways: worsening trouble breathing, coughing, wheezing
  • Heart problems: faster heart rate, dizziness, chest pain
  • Serious allergic reaction: skin rash, itching, hives, swelling of your face or tongue, difficulty breathing, chest pain
When do Levalbuterol (Xopenex HFA) possible side effects begin and end?
Time passed since treatment started:
M
H
D
W
M
Tremors
Dizziness
Sore throat

Source: DailyMed

The following Levalbuterol (Xopenex HFA) side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Fast heartbeat

Less common

Chest pain or tightness

dizziness

feeling “faint”

lightheadedness

troubled breathing

Incidence not known

Confusion

cough

difficult or labored breathing

difficulty swallowing

drowsiness

extra heartbeat

fainting

fast, pounding, slow, or irregular heartbeat or pulse

hives, welts, itching, or rash

large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals

nausea

noisy breathing

rapid, deep breathing

redness of the skin

restlessness

stomach cramps

unusual tiredness or weakness

vomiting

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Chest pain

dizziness

dry mouth

general feeling of discomfort or illness

headache

impaired consciousness

irregular or fast heartbeat

lightheadedness

nausea

nervousness

seizures

sleeplessness

sweating

tremor

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Accidental injury (in children 4 to 11 years of age)

anxiety

body aches or pain

chills

congestion

cough

dryness or soreness of the throat

fever

general aches and pains

headache

hoarseness

increased cough

leg cramps

loss of appetite

migraines or other headaches

muscle tightness

nervousness

runny or stuffy nose

Less common

Abnormal growth filled with fluid or semisolid material

blemishes on the skin

blood in the urine

bloody nose

burning, dry, or itching eyes

burning or stinging of the skin

cough producing mucus

cramps

diarrhea

difficulty having a bowel movement

discharge from the eye

dry mouth or throat

ear pain

excessive tearing

eye itch

heavy menstrual bleeding

muscle pain

night sweats

numbness or decreased sensitivity of the hand

pain

painful cold sores or blisters on the lips, nose, eyes, or genitals

pimples

redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

stomach pain

tingling sensation in the arms or legs

vaginal yeast infection

weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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pros-and-cons-icon

Pros and cons of Levalbuterol (Xopenex HFA)

Pros

  • Works within minutes to help you breathe easier
  • Only used as needed
  • Safe for children as young as 4 years old

Cons

  • Not a long-term asthma control medications
  • Can cause side effects like tremor or fast heart rate
  • Some people might find the inhaler difficult to use
pharmacist-tips-icon

Pharmacist tips for Levalbuterol (Xopenex HFA)

pharmacist
  • Keep levalbuterol (Xopenex HFA) with you at all times. It's a rescue inhaler for sudden shortness of breath if needed.
  • Check the dose counter on your levalbuterol (Xopenex HFA) inhaler. Refill it when the number turns red and shows 20 puffs left. Throw it away when the counter reads “0,” even if it still feels like there's medication inside.
  • Get medical help if your breathing doesn't improve or gets worse after using levalbuterol (Xopenex HFA). Tell your prescriber if you need to use it more often than usual. This could mean your treatment plan needs to change.
  • Levalbuterol (Xopenex HFA) can cause side effects like a fast heartbeat, chest pain, shaking, or feeling nervous. Tell your prescriber if these bother you or do not go away.
  • Ask your prescriber or pharmacist before starting new medications while using levalbuterol (Xopenex HFA). It can interact with other medications, such as beta blockers, certain antidepressants, and digoxin. These interactions can affect how your medications work or raise your risk of side effects.
  • If you have trouble using levalbuterol (Xopenex HFA), ask about using a spacer. A spacer attaches to your inhaler and makes it easier to breathe in the medication.

How to use levalbuterol (Xopenex HFA):

  • Carefully read the instructions on how to use your inhaler and ask your prescriber or pharmacist if you have any questions.
  • Priming the inhaler: If your levalbuterol (Xopenex HFA) inhaler is new or hasn't been used in more than 3 days, you need to prime it. Shake it well, point it away from your face, and spray it 4 times.
  • Taking a dose: Before each dose, shake it for about 5 seconds. Seal your lips around the mouthpiece, breathe in slowly and deeply, and press the canister. Hold your breath for up to 10 seconds if you can.
  • If you need more than one puff of levalbuterol (Xopenex HFA), wait at least 1 minute between puffs.
  • After use: Clean the mouthpiece at least once a week. To do so, remove the cap and canister and set them aside. Then rinse the mouthpiece with warm water for 30 seconds, and let it air dry completely before putting it back together.
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Risks and warnings for Levalbuterol (Xopenex HFA)

Levalbuterol (Xopenex HFA) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

Sudden narrowing of the airways

  • Risk factor: First use of a new canister

Levalbuterol (Xopenex HFA) can sometimes cause a sudden tightening of the airways called paradoxical bronchospasm, meaning your breathing might get worse instead of better. This can be life-threatening and often happens the first time you use a new inhaler canister. If you notice more wheezing, coughing, or shortness of breath after using it, stop the medication right away and contact your prescriber.

Worsening asthma

If you're still having symptoms after using levalbuterol (Xopenex HFA), or if you need to use it more often than usual, your asthma could be getting worse. Talk to your prescriber as soon as possible so they can check your condition and adjust your treatment if needed.

Heart problems

  • Risk factors: History of heart problems | High blood pressure | Using more levalbuterol (Xopenex HFA) than recommended

Levalbuterol (Xopenex HFA) can affect your heart. It might cause a faster heartbeat, higher blood pressure, or changes in heart rhythm. Tell your prescriber if you notice these symptoms since they might tell you to stop using it.

Don't use levalbuterol (Xopenex HFA) more often than recommended since this can raise your risk of heart problems. Talk to your prescriber before starting this medication if you have heart disease or high blood pressure.

Serious allergic reaction

  • Risk factors: History of allergy to albuterol

In rare cases, levalbuterol (Xopenex HFA) can cause a serious allergic reaction. Don't use this medication if you're allergic to albuterol since this could increase your risk of a reaction. Get medical help right away if you have a rash, itching, swelling of your face or tongue, trouble breathing, or chest pain.

Worsening of certain health conditions

  • Risk factors: Using too much levalbuterol (Xopenex HFA) | High thyroid hormone | History of seizures | Diabetes

Speak to your prescriber before using levalbuterol (Xopenex HFA) if you have health conditions like seizures, high thyroid hormone, or diabetes. This inhaler can sometimes make these conditions worse or lead to serious side effects. Be sure to share your full medical history with your prescriber before starting this medication.

Low potassium levels

  • Risk factor: Taking medications that can lower potassium levels

Levalbuterol (Xopenex HFA) can sometimes cause low potassium levels, though this is usually temporary and doesn’t need treatment. But in some cases, low potassium can affect your heart. Let your care team know if you have muscle pain or weakness, muscle cramps, or an irregular heartbeat — these could be signs of low potassium.

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Levalbuterol (Xopenex HFA) dosage

The average cost for 1 inhaler of 15g of 45mcg of Levalbuterol (Xopenex HFA) is $55.25 with a free GoodRx coupon.
inhalerInhaler
DosageQuantityPrice as low asPrice per unit
15g of 45mcg1 inhaler$55.25$55.25
vialVial
DosageQuantityPrice as low asPrice per unit
0.5ml of 1.25mg/0.5ml60 vials$52.83$0.88
3ml of 0.31mg/3ml25 vials$24.25$0.97
3ml of 0.63mg/3ml25 vials$33.80$1.35
3ml of 1.25mg/3ml25 vials$33.86$1.35

Typical dosage for Levalbuterol (Xopenex HFA)

Each inhalation delivers 45 mcg of levalbuterol into the lungs.

The typical dose is 1 to 2 inhalations through the mouth every 4 to 6 hours.

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Interactions between Levalbuterol (Xopenex HFA) and other drugs

Levalbuterol (Xopenex HFA) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Levalbuterol (Xopenex HFA). Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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How much does Levalbuterol (Xopenex HFA) cost?

To access savings, use a GoodRx coupon and pay just a fraction of the retail price.
Levalbuterol (Xopenex HFA) (generic)
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$24.25

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Levalbuterol (Xopenex HFA) contraindications

Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Levalbuterol (Xopenex HFA) will not be safe for you to take.

  • Allergy to levalbuterol (Xopenex HFA) or albuterol
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What are alternatives to Levalbuterol (Xopenex HFA)?

There are a number of medications that your doctor can prescribe in place of Levalbuterol (Xopenex HFA). Compare a few possible alternatives below.
Levalbuterol (Xopenex HFA)
Used for:
  • Treat or prevent tightening of airways in adults and children 4 years and older with certain breathing problems, such as asthma
$24.25Lowest GoodRx priceView prices
Used for:
  • Treatment or prevention of wheezing or tightening of airways in people ages 4 years and older with certain types of lung problems (e.g., asthma)
  • Prevention of exercise-induced asthma in people ages 4 years and older
$14.52Lowest GoodRx priceView prices
Used for:
  • Treatment or prevention of wheezing or tightening of airways in people ages 6 years and older with certain types of lung problems (e.g., asthma)
$24.25Lowest GoodRx priceView prices
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News about Levalbuterol (Xopenex HFA)

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Levalbuterol (Xopenex HFA) images

colorless - Levalbuterol Tartrate 45mcg/actuation Inhalation Aerosol
This medicine is Colorless Inhaler.colorless - Levalbuterol Tartrate 45mcg/actuation Inhalation Aerosol

References

Best studies we found

Ameredes, B. T., et al. (2009). Levalbuterol versus albuterol. Current Allergy and Asthma Reports.

Lupin Pharmaceuticals, Inc. (2025). XOPENEX HFA- levalbuterol tartrate aerosol, metered [package insert]. DailyMed.

Magee, J. S., et al. (2018). Paradoxical bronchoconstriction with short-acting beta agonist. The American Journal of Case Reports.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.