Dutasteride / Tamsulosin
Jalyn (dutasteride / tamsulosin) is a combination medication used to relieve symptoms of enlarged prostate (benign prostatic hyperplasia or BPH). Although it works well, it can cause problems with ejaculation, erection, and your sex drive.
What is Jalyn (dutasteride / tamsulosin)?
What is Jalyn (dutasteride / tamsulosin) used for?
- Symptoms caused by enlarged prostate (benign prostatic hyperplasia or BPH)
How Jalyn (dutasteride / tamsulosin) works
Jalyn (dutasteride / tamsulosin) is a combination of two medications that work in different ways to relieve your BPH symptoms.
- Dutasteride is a 5-alpha reductase inhibitor. It blocks 5-alpa reductase, a protein that breaks down testosterone to a hormone called dihydrotestosterone (DHT). DHT is the hormone responsible for enlarging your prostate. By lowering DHT levels, dutasteride stops your prostate from growing.
- Tamsulosin is an alpha-1 adrenergic receptor blocker. It blocks alpha-1 receptors in your prostate. This causes the muscles around the bladder and prostate to relax so you have less of an urge to urinate and so your urine flows better.
Drug facts
Side effects of Jalyn (dutasteride / tamsulosin)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Ejaculation problems
- Trouble keeping an erection (impotence)
- Lower sex drive
- Breast enlargement and tenderness
- Dizziness
Less Common Side Effects
- Drop in blood pressure upon standing (orthostatic hypotension)
Jalyn (dutasteride / tamsulosin) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Prolonged, unwanted erection (priapism)
The following Jalyn (dutasteride / tamsulosin) side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Chills
cold sweats
confusion
dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
Incidence not known
Blistering, flaking, or peeling of the skin
blurred vision
difficulty with breathing
fast, irregular, pounding, or racing heartbeat or pulse
large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
pain or swelling of the treated skin
painful or prolonged erection of the penis
sweating
trouble breathing
unusual tiredness or weakness
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Change or problem with discharge of semen
decreased interest in sexual intercourse
dizziness
enlarged and painful breasts
inability to have or keep an erection
loss in sexual ability, desire, drive, or performance
Less common
Back pain
body aches or pain
congestion
dryness or soreness of the throat
headache
increased cough
lack or loss of strength
pain or tenderness around the eyes and cheekbones
sleepiness or unusual drowsiness
tender, swollen glands in the neck
tightness of the chest
trouble sleeping
trouble with swallowing
unable to sleep
voice changes
Incidence not known
Bloody nose
hives or welts, itching, skin rash
joint or muscle pain
red irritated eyes
red skin lesion, often with a purple center
redness of the skin
sores, ulcers, or white spots in the mouth or on the lips
vomiting
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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Pros and cons of Jalyn (dutasteride / tamsulosin)
Pros
- Combines two different medications into one in order to relieve your BPH symptoms
- Taken once a day
- Available in a lower-cost, generic form
Cons
- Can cause a sudden drop in your blood pressure upon standing
- Can cause problems with ejaculation, erection, and your sex drive
- Can interact with other medications
Pharmacist tips for Jalyn (dutasteride / tamsulosin)
- Take Jalyn (dutasteride / tamsulosin) 30 minutes after the same meal every day. Swallow the capsule whole, don't chew, open, or crush the capsule.
- Jalyn (dutasteride / tamsulosin) can cause a sudden drop in your blood pressure when you stand. This can cause dizziness, vertigo (spinning), or fainting. If you feel these symptoms, sit or lie down right away so you don't fall.
- Don't use Jalyn (dutasteride / tamsulosin) if you've had a serious allergic reaction to sulfa medications, such as Bactrim or Septra (sulfamethoxazole / trimethoprim), sulfasalazine (Azulfidine), and sumatriptan (Imitrex). Although rare, patients with an allergy to sulfa medications can have an allergic reaction to Jalyn (dutasteride / tamsulosin).
- Women who are pregnant or are potentially pregnant should not touch this medication. Jalyn (dutasteride / tamsulosin) can be absorbed through the skin and cause damage to an unborn, male baby's genitals. If a pregnant woman accidentally touches Jalyn (dutasteride / tamsulosin), they should wash their hands with soap and water right away.
- Although it's rare, Jalyn (dutasteride / tamsulosin) can cause prolonged, painful erections (priapism) unrelated to sexual activity. If this happens, get medical care right away to avoid any permanent damage.
- Store Jalyn (dutasteride / tamsulosin) at room temperature. It can get discolored or deformed if it's kept in really hot temperatures. Don't take the medication if it changes color or shape.
Common questions about Jalyn (dutasteride / tamsulosin)
It can take 3 months to see improvement in your BPH symptoms. It's important that you continue to take Jalyn (dutasteride / tamsulosin) every day even if you don't see improvement in your symptoms immediately.
In some studies, Jalyn (dutasteride / tamsulosin) lowered sperm count, semen volume, and sperm movement while people were taking the medication. Participants' total sperm count was still lower even 24 weeks after they stopped taking Jalyn (dutasteride / tamsulosin). It isn’t known whether these effects can affect your ability to have children.
No, you shouldn't donate blood until at least 6 months after your last dose of Jalyn (dutasteride / tamsulosin). This is to prevent any pregnant woman who receives the blood transfusion from being exposed to Jalyn (dutasteride / tamsulosin). Jalyn (dutasteride / tamsulosin) can cause damage to an unborn, male baby's genitals.
You can take Jalyn (dutasteride / tamsulosin) later that same day, 30 minutes after a meal. If you miss several days in a row, talk to your provider before you start taking the medication again. Don't take 2 Jalyn (dutasteride / tamsulosin) doses in 1 day.
Taking Jalyn (dutasteride / tamsulosin) and erectile dysfunction medications together can lower your blood pressure. This can cause dizziness, lightheadedness, or fainting. Let your provider know if you're taking erectile dysfunction medications before you start Jalyn (dutasteride / tamsulosin).
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Risks and warnings for Jalyn (dutasteride / tamsulosin)
Jalyn (dutasteride / tamsulosin) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Drop in blood pressure upon standing
- Risk factors: Taking blood pressure medications | Taking medications for erectile dysfunction
Jalyn (dutasteride / tamsulosin) can cause a big drop in blood pressure when you stand up from a sitting or lying down position. This can make you feel dizzy or it can make you faint. It's more likely to happen when you take your first dose. It can also occur if your treatment gets interrupted, if your dose is raised, or if you start taking other blood pressure or erectile dysfunction medications at the same time. Be cautious with activity when you first start Jalyn (dutasteride / tamsulosin) or increase your dose.
Prostate cancer and screenings
Jalyn (dutasteride / tamsulosin) might slightly increase your risk of aggressive prostate cancer, but overall, studies showed your risk of prostate cancer is lower if you take Jalyn (dutasteride / tamsulosin).
Jalyn (dutasteride / tamsulosin) can lower prostate-specific antigen (PSA) levels in your body, which can affect the results of a prostate cancer test. Your provider will likely monitor your PSA levels periodically while you take Jalyn (dutasteride / tamsulosin).
Floppy iris syndrome
- Risk factors: Planned cataract or glaucoma surgery
Jalyn (dutasteride / tamsulosin) can cause floppy iris syndrome (FIS), which is an issue that can occur during cataract surgery. FIS can raise your risk of having eye problems during and after cataract surgery. Let your eye provider know if you're taking Jalyn (dutasteride / tamsulosin) because you might need to stop the medication or your provider might need to change their surgical technique.
Interactions with other medications
Jalyn (dutasteride / tamsulosin) can interact with many medications, such as certain mental health medications, erectile dysfunction medications, and blood thinners, so it's important that you check with your provider or pharmacist to see if it's safe for you to start Jalyn (dutasteride / tamsulosin). If Jalyn (dutasteride / tamsulosin) is taken at the same time as certain medications, it can raise your risk of side effects.
Prolonged penile erection
Although it's rare, Jalyn (dutasteride / tamsulosin) can cause prolonged, unwanted penile erection lasting longer than 4 hours. This can have permanent effects. Get medical care right away if this occurs.
Jalyn (dutasteride / tamsulosin) dosage
Capsule| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 0.5mg/0.4mg | 90 capsules | $109.81 | $1.22 |
Typical dosage for Jalyn (dutasteride / tamsulosin)
The typical dose is 1 capsule by mouth about 30 minutes after the same meal every day. Each capsule contains 0.5 mg of dutasteride and 0.4 mg of tamsulosin.
Interactions between Jalyn (dutasteride / tamsulosin) and other drugs
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.
- Boceprevir
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Alfuzosin
- Bunazosin
- Ceritinib
- Clarithromycin
- Cobicistat
- Conivaptan
- Dapiprazole
- Doxazosin
- Idelalisib
- Indinavir
- Itraconazole
- Ketoconazole
- Lopinavir
- Moxisylyte
- Nefazodone
- Nelfinavir
- Paroxetine
- Phenoxybenzamine
- Phentolamine
- Posaconazole
- Prazosin
- Ritonavir
- Saquinavir
- Silodosin
- Tadalafil
- Telaprevir
- Telithromycin
- Terazosin
- Tolazoline
- Trimazosin
- Urapidil
- Voriconazole
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Acebutolol
- Alprenolol
- Atenolol
- Avanafil
- Betaxolol
- Bevantolol
- Bisoprolol
- Bucindolol
- Carteolol
- Carvedilol
- Celiprolol
- Cimetidine
- Ciprofloxacin
- Dilevalol
- Diltiazem
- Esmolol
- Ketoconazole
- Labetalol
- Levobunolol
- Mepindolol
- Metipranolol
- Metoprolol
- Nadolol
- Nebivolol
- Oxprenolol
- Penbutolol
- Pindolol
- Propranolol
- Ritonavir
- Sildenafil
- Sotalol
- Talinolol
- Tertatolol
- Timolol
- Vardenafil
- Verapamil
How much does Jalyn (dutasteride / tamsulosin) cost?
Jalyn (dutasteride / tamsulosin) contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Jalyn (dutasteride / tamsulosin) will not be safe for you to take.
- Currently pregnant
- Allergy to Jalyn (dutasteride / tamsulosin)
What are alternatives to Jalyn (dutasteride / tamsulosin)?
Jalyn (dutasteride / tamsulosin) images
