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Ibsrela Coupon - Ibsrela 50mg tablet

Ibsrela

tenapanor
Used for Constipation, Irritable Bowel Syndrome
Used for Constipation, Irritable Bowel Syndrome

Ibsrela (tenapanor) is used to treat adults with irritable bowel syndrome with constipation (IBS-C). This medication belongs to the drug class called sodium/hydrogen exchanger 3 (NHE3) inhibitors. Ibsrela (tenapanor) is a tablet that's taken by mouth twice per day. There aren't many side effects, but the most common is diarrhea. Other side effects include bloating, gas, and dizziness.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Allison Gourley, PharmD
Last reviewed on May 7, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageContraindicationsAlternativesImagesReferencesPricesMedicare
basics-icon

What is Ibsrela (tenapanor)?

What is Ibsrela (tenapanor) used for?

How Ibsrela (tenapanor) works

Ibsrela (tenapanor) is a sodium/hydrogen exchanger 3 (NHE3) inhibitor.

It works by preventing sodium from getting absorbed into your body from your gut. This causes more water to go into your intestines to soften stool and keeps your stool moving along in your gut so you can go to the bathroom.

Ibsrela (tenapanor) also works on the nerves in your gut to help to relieve stomach pain.

Are you looking for information on Xphozah (tenapanor) instead?
When does Ibsrela (tenapanor) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Initial effect
Full effect

Drug Facts

Common BrandsIbsrela
Drug ClassSodium/hydrogen exchanger 3 (NHE3) inhibitor
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
basics-icon

What are the side effects of Ibsrela (tenapanor)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Diarrhea (16%)
  • Stomach bloating (3%)
  • Gas (3%)
  • Dizziness (2%)

Other Side Effects

  • Bleeding at the rectum
  • Unusual stomach sounds

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Severe dehydration: dry skin, extreme thirst, fast heartbeat, fast breathing, can't urinate, very dark yellow urine, tiredness, confusion, headache, dizziness, fainting
  • Severe diarrhea
When do Ibsrela (tenapanor) possible side effects begin and end?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Diarrhea

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
  • Dehydration—increased thirst, dry mouth, feeling faint or lightheaded, headache, dark yellow or brown urine
  • Severe or prolonged diarrhea

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Ibsrela (tenapanor)

thumbs-up

Pros

Recommended for people with IBS-C who've already tried other therapies

Can help lessen episodes of stomach pain and constipation

Symptoms can start to improve within a week

thumbs-down

Cons

Need to take right before a meal twice daily

Can cause diarrhea and dehydration

Not safe for children

pharmacist-tips

Pharmacist tips for Ibsrela (tenapanor)

pharmacist

  • Take Ibsrela (tenapanor) 5 to 10 minutes before breakfast and dinner.

    • Let your prescriber know right away if you have diarrhea while you're taking Ibsrela (tenapanor). Studies showed that diarrhea tends to go away within a week. Depending on how bad your diarrhea is, your prescriber might recommend temporarily stopping the medication until the diarrhea goes away. Drink plenty of fluids with electrolytes to prevent dehydration from diarrhea.

      • If you forget to take your dose of Ibsrela (tenapanor), skip the missed dose and take the next dose at the regular time. Don't take two doses at once to make up for the missed dose. Doing so can raise your risk of side effects like diarrhea and dehydration.

        • Keep Ibsrela (tenapanor) in the original bottle tightly closed with the desiccant (drying agent) inside. It's important to protect the tablets from moisture because it can damage the medication.

          • Keep Ibsrela (tenapanor) out of reach of children, especially those under 6 years old. Children who accidentally take Ibsrela (tenapanor) might have severe diarrhea and dehydration, which can lead to serious problems. Contact 911 or the poison control center (1-800-222-1222) right away if a child has accidentally taken Ibsrela (tenapanor).

            • Let your healthcare team know if you're pregnant, thinking of becoming pregnant, or are breastfeeding. It's not completely known how safe Ibsrela (tenapanor) is for an unborn or breastfed baby. But available data suggests that it might be safe because most of the medication doesn't get absorbed into the body. Discuss with your prescriber about the risks and benefits of taking Ibsrela (tenapanor).

              faqs

              Frequently asked questions about Ibsrela (tenapanor)

              How long does it take for Ibsrela (tenapanor) to work?
              In clinical studies, people started to feel improvement in IBS-C symptoms like constipation and stomach pain within 1 week of starting Ibsrela (tenapanor). But it can take several weeks or a few months to feel the full effects of the medication. Contact your prescriber if you're concerned with how well Ibsrela (tenapanor) is working for you.
              Does Ibsrela (tenapanor) cause weight gain?
              No, Ibsrela (tenapanor) doesn't appear to cause weight gain. Weight gain wasn't a side effect that people reported while they took the medication during clinical studies. Contact your primary care provider if you notice unusual or concerning weight gain after you start taking Ibsrela (tenapanor). You might need to be examined for other potential causes.
              Does Ibsrela (tenapanor) cause weight loss?
              No, Ibsrela (tenapanor) doesn't make you lose weight. However, the medication can cause diarrhea as a side effect. Severe or long-lasting diarrhea can sometimes lead to weight loss. It's important to stay hydrated if you have diarrhea to prevent dehydration and unintentional weight loss. Let your prescriber know if you experience concerning weight loss, especially if you've had episodes of diarrhea and if you're also feeling weak, dizzy, or faint. These can be signs that you're dehydrated.
              Can you take Ibsrela (tenapanor) after you eat?
              You should take Ibsrela (tenapanor) about 5 to 10 minutes before breakfast and dinner. Studies show that taking Ibsrela (tenapanor) after you eat might make the medication work less well.
              Is Ibsrela (tenapanor) a laxative?
              Yes, Ibsrela (tenapanor) can be considered a laxative. Laxatives are medications that work in your intestines to help you have bowel movements and provide relief from constipation. This particular laxative works to treat IBS-C by pulling water into the gut to help soften stool and cause more bowel movements.
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              What are the risks and warnings for Ibsrela (tenapanor)?

              Ibsrela (tenapanor) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Serious dehydration in children

              • Risk factors: Children under 6 years old

                Children can't take Ibsrela (tenapanor). It's not known how well or how safe the medication is for them. Additionally, they're at higher risk for severe dehydration after they take Ibsrela (tenapanor). Discuss available safe treatment options with the specialist if your child has IBS-C.

                risk-warning

                Diarrhea

                Diarrhea is typically the most common side effect of Ibsrela (tenapanor). During studies, people reported having mild-to-moderate diarrhea that often started at the beginning of treatment and lasted a week or less. Tell your prescriber if you have diarrhea because it can raise your risk of getting dehydrated, which can be a medical emergency. Make sure to stay hydrated while you're taking this medication. Contact your prescriber right away if you have severe diarrhea.

                dosage

                Ibsrela (tenapanor) dosage forms

                Typical dosing for Ibsrela (tenapanor)

                The typical dose is 50 mg by mouth two times daily, right before breakfast and right before dinner.

                contraindications-icon

                Ibsrela (tenapanor) contraindications

                Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Ibsrela (tenapanor) will not be safe for you to take.

                • Children younger than 6 years old

                • Known or suspected physical blockage in the gut or digestive system that interrupts normal passage

                alternatives

                What are alternatives to Ibsrela (tenapanor)?

                There are a number of medications that your doctor can prescribe in place of Ibsrela (tenapanor). Compare a few possible alternatives below.
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                Linzess (linaclotide)
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                images

                Ibsrela (tenapanor) images

                White Oval Logo 50 And 5791 - IBSRELA 50mg Tablet
                This medicine is White, Oval Tablet Imprinted With "5791" And "Logo 50".White Oval Logo 50 And 5791 - IBSRELA 50mg Tablet

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                References

                Best studies we found

                American Gastroenterological Association. (2022). New AGA guidelines: A targeted approach to IBS-C and IBS-D treatment.

                Ardelyx, Inc. (2022). Isbrela- tenapanor hydrochloride tablet [package insert]. DailyMed.

                Bashir A., et al. (2024). Laxatives. StatPearls.

                View All References (2)

                Chey, W. D., et al. (2021). Efficacy of tenapanor in treating patients with irritable bowel syndrome with constipation: A 26-week, placebo-controlled phase 3 trial (T3MPO-2). The American Journal of Gastroenterology.

                Lembo, A. J., et al. (2023). Long-term safety of tenapanor in patients with irritable bowel syndrome with constipation in the T3MPO-3 study. Neurogastroenterology & Motility.

                GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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