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Ebglyss

lebrikizumab
Used for Eczema
Used for Eczema

Ebglyss (lebrikizumab or lebrikizumab-lbkz) is an injectable medication that’s used to treat moderate-to-severe eczema. It’s approved for people 12 years of age and older who weigh at least 88 lbs. This medication is an interleukin-13 antagonist, which works to reduce swelling and discomfort of the skin caused by eczema. Ebglyss (lebrikizumab) is used when topical products aren’t working well enough or when you can’t use them at all. Some people have had side effects like pink eye and pain around the injection site while using Ebglyss (lebrikizumab).

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What is Ebglyss (lebrikizumab)?

What is Ebglyss (lebrikizumab) used for?

How Ebglyss (lebrikizumab) works

Ebglyss (lebrikizumab) is a type of monoclonal antibody called an interleukin-13 (IL-13) antagonist. It blocks a protein in your body called IL-13, which plays a role in causing eczema. By blocking IL-13, Ebglyss (lebrikizumab) helps to decrease swelling and irritation in the skin.

Are you looking for information on Eliquis (apixaban) instead?
When does Ebglyss (lebrikizumab) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Full effect

Drug Facts

Common BrandsEbglyss
Drug ClassInterleukin-13 antagonist
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the side effects of Ebglyss (lebrikizumab)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Pink eye (10%)
  • Injection site reactions (e.g. pain, swelling, redness; 3%)

Other Side Effects

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Allergic reaction: breathing problems; swelling of the face, lips, mouth, tongue, or throat; hives; itching; stomach cramps; dizziness
  • Eye problems: eye pain, changes in vision, blurred vision
When do Ebglyss (lebrikizumab) possible side effects begin and end?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Injection site reactions

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Pain, redness, or irritation at injection site
pros-and-cons

Pros and cons of Ebglyss (lebrikizumab)

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Pros

Can use with or without topical corticosteroids

Approved for eczema in certain children 12 years of age and older who weigh at least 88 pounds

Injected once every two or four weeks

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Cons

Must inject under the skin

Can increase the risk of pink eye

Can’t get any live vaccines during treatment

pharmacist-tips

Pharmacist tips for Ebglyss (lebrikizumab)

pharmacist
  • You can inject Ebglyss (lebrikizumab) yourself or have a caregiver help you. But both of you must get trained by a healthcare professional first. They’ll teach you how to safely inject the medication under the skin.

    • Inject Ebglyss (lebrikizumab) under the skin in your stomach, thigh, or upper arm. If you use your upper arm, have someone help you inject it. Rotate injection sites to avoid scarring and discomfort. You can use the same general area on your body, but don’t put the needle in the same spot every time.

      • Follow the dosing schedule for your Ebglyss (lebrikizumab) injections. You can use a calendar reminder or alarm to help remember when your injections are. If you miss a dose, inject it as soon as you remember. Then, inject your next dose that’s on your regular schedule.

        • Some people can have swelling, redness, or warmth at the injection site within a few hours after using Ebglyss (lebrikizumab). This usually goes away within 1 to 2 days. Try using warm compresses, ice packs, and over-the-counter pain medications to relieve symptoms. If your symptoms worsen after a day, tell your prescriber.

          • Tell your primary care provider and pharmacist if you plan on getting any vaccines while taking Ebglyss (lebrikizumab). This medication can change your immune response to some vaccines. Avoid live vaccines while you’re taking Ebglyss (lebrikizumab) since you might be more likely to get sick from the vaccine.

            • Store Ebglyss (lebrikizumab) in the refrigerator and keep it in its original carton to protect it from light. Don’t freeze or shake it. If needed, you can also store it at room temperature (up to 86°F) for up to 7 days before you have to throw it away.

              How to inject Ebglyss (lebrikizumab) using the prefilled pen

              • Make sure the pen is locked. When you’re ready, uncap the pen by twisting off the gray base cap.

                • Place and hold the clear base flat against your skin. Then, unlock the pen. With the pen still against your skin, press and hold the purple injection button for 15 seconds. Listen for two loud clicks before removing it from your skin. The first click tells you that the injection started and the second one means that it’s complete.

                  How to inject Ebglyss (lebrikizumab) using the prefilled syringe

                  • Before you inject, let the syringe sit out at room temperature for 45 minutes. Don’t microwave it, run it under hot water, or leave it in direct sunlight to warm it up. This could damage the medication.

                    • When you’re ready, hold the syringe in the middle and pull the needle cap straight off. Gently pinch a fold of skin with one hand and insert the needle at a 45° angle with your other hand. Relax the pinch once the needle is fully into the skin. Then, push the plunger all the way down to inject the medication.

                      • Let go of the plunger until the needle is completely hidden by the shield. You can press a cotton ball to the area where you injected the medication if you see blood (don’t rub the skin).

                        • After each injection, throw the used syringe away in a sharps container or an approved household container. Sharps containers protect people from accidental needle sticks.

                          More on Ebglyss (lebrikizumab) tips

                          faqs

                          Frequently asked questions about Ebglyss (lebrikizumab)

                          How well does Ebglyss (lebrikizumab) work for eczema?
                          Two studies showed that Ebglyss (lebrikizumab) helped more people have clear or almost clear skin than placebo. In one study, 43% of people taking Ebglyss (lebrikizumab) saw this improvement in their skin after 4 months. And in the other study, 33% of people taking Ebglyss (lebrikizumab) had clear or almost clear skin after the same amount of time. Follow up with your prescriber about how well Ebglyss (lebrikizumab) might work for your eczema.
                          How long do I need to take Ebglyss (lebrikizumab)?
                          The first part of treatment takes at least 16 weeks (or almost 4 months). You’ll inject Ebglyss (lebrikizumab) every 2 weeks to help clear your eczema. Once your skin clears up, you’ll start maintenance treatment, which doesn’t have a set end date. You'll keep injecting Ebglyss (lebrikizumab) every 4 weeks, even if your symptoms have already improved. This helps your eczema stay under control and prevent flare ups. Follow up with your prescriber even after your eczema gets better. Talk to a healthcare professional if you have any side effects that bother you. Also talk to them first if you want to change eczema medications or stop treatment for any reason. They'll discuss next steps with you.
                          How fast does Ebglyss (lebrikizumab) work for eczema?
                          In clinical trials, some people had clear or almost clear skin by week 4 of treatment with Ebglyss (lebrikizumab). Some people also had less itchiness by week 4. For other people, it took up to 4 months of treatment to get rid of eczema. Ask your prescriber if you have questions about how fast Ebglyss (lebrikizumab) can help improve your eczema.
                          Where should I inject my Ebglyss (lebrikizumab)?
                          You can inject Ebglyss (lebrikizumab) under the skin in the stomach area, but avoid the space within 2 inches of your belly button. Another place you can inject into is the thigh. You can also choose to inject Ebglyss (lebrikizumab) into the back of your upper arm. But it’s best to have someone else assist you in this situation. Make sure you rotate injection sites so that your skin doesn’t get scarred and sore. You should only inject the medication into healthy areas of the skin. Avoid any areas where there’s eczema, bruising, or redness.
                          What should I do if my Ebglyss (lebrikizumab) looks cloudy or discolored?
                          Don’t use your Ebglyss (lebrikizumab) if it has particles in it or looks cloudy. It should be clear or translucent and slightly yellow to brown. Let your primary care provider know as soon as possible that your medication doesn’t look right. They can work to get you another one from the pharmacy.
                          Should I warm up my Ebglyss (lebrikizumab) before I inject it?
                          If you’re using the Ebglyss (lebrikizumab) prefilled pen, you don’t need to warm it up to room temperature before you inject the medication. If you’re using the Ebglyss (lebrikizumab) prefilled syringe, leave it at room temperature for 45 minutes with the needle cap on before injecting. Don’t microwave the medication, run hot water over it, or leave it in the direct sunlight. Direct heat or light might damage the medication.
                          Is Ebglyss (lebrikizumab) safe to use during pregnancy?
                          It’s unknown if Ebglyss (lebrikizumab) is safe to use during pregnancy. Talk to your primary care provider or obstetrician-gynecologist (OB-GYN) about the risks and benefits of this medication. If you become pregnant during treatment, tell your primary care provider so they can consider alternatives, like a topical steroid. You or your primary care provider can also call Eli Lilly at 1-800-5979 to report the pregnancy.
                          Is Ebglyss (lebrikizumab) safe to use while breastfeeding?
                          It’s unknown if Ebglyss (lebrikizumab) is safe to use while breastfeeding. Talk to your primary care provider about safer options, like topical steroids. If you want to use Ebglyss (lebrikizumab), speak with your primary care provider about alternative feeding options like baby formula.
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                          What are the risks and warnings for Ebglyss (lebrikizumab)?

                          Ebglyss (lebrikizumab) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                          risk-warning

                          Risk of allergic reaction

                          Swelling of the face, lips, or tongue have occurred after taking Ebglyss (lebrikizumab). Some people have also experienced hives. Stop taking Ebglyss (lebrikizumab) and seek help if you notice any of these reactions.

                          risk-warning

                          Risk of pink eye and inflammation of the cornea

                          Studies showed that the risk of pink eye was higher in people taking Ebglyss (lebrikizumab) than those who weren’t taking any medication. These cases included both allergic and bacterial pink eye during the first 4 months of treatment. Other people also reported inflammation of the cornea, with symptoms like eye redness and pain. Most times, these eye problems were mild or moderate and went away on their own. Let your primary care provider know about any new or worsening eye symptoms to prevent permanent damage.

                          risk-warning

                          Use with caution in people with parasitic (worm) infections

                          Ebglyss (lebrikizumab) wasn’t tested in people with parasitic (worm) infections. So, we don’t know if this medication will change how your immune system fights these infections.

                          Before starting Ebglyss (lebrikizumab), make sure any parasitic infections are treated. If you get a parasitic worm infection while taking this medication, let your prescriber know so you can start treatment to kill the bug. If the infection doesn’t go away, you’ll probably have to stop using Ebglyss (lebrikizumab) until it clears up.

                          risk-warning

                          Risk of infection with live vaccinations

                          Avoid getting any live vaccines right before starting treatment and also while taking Ebglyss (lebrikizumab). Live vaccines contain weakened germs, which your body can normally fight. But Ebglyss (lebrikizumab) can weaken your immune response, which can increase your risk of infection from live vaccines.

                          Tell your primary care provider that you’re taking Ebglyss (lebrikizumab) before getting any vaccines. Even though you can’t get live vaccines, you may still be able to get some other vaccines. This includes the flu shot that’s injected into the muscle.

                          dosage

                          Ebglyss (lebrikizumab) dosage forms

                          Typical dosing for Ebglyss (lebrikizumab)

                          You’ll typically follow a dosing schedule below:

                          • Week 0 (when you start the medication): The dose is two 250 mg injections (500 mg) under your skin once.

                          • Week 2: The dose is two 250 mg injections (500 mg) under your skin once.

                          • Weeks 4 through 16 (or until symptoms are controlled): The dose is one 250 mg injection under your skin every two weeks.

                          • The following weeks (maintenance): The dose is one 250 mg injection under your skin every four weeks.

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                          How much does Ebglyss (lebrikizumab) cost?

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                          alternatives

                          What are alternatives to Ebglyss (lebrikizumab)?

                          There are a number of medications that your doctor can prescribe in place of Ebglyss (lebrikizumab). Compare a few possible alternatives below.
                          Ebglyss (lebrikizumab)
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                          • Inflammatory skin conditions

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                          References

                          Best studies we found

                          Bieber, T. (2019). Interleukin-13: Targeting an underestimated cytokine in atopic dermatitis. Allergy.

                          Centers for Disease Control and Prevention. (n.d.). Conjunctivitis (pink eye).

                          Centers for Disease Control and Prevention. (2024). About parasites.

                          View All References (10)

                          Eli Lilly and Company. (2024). Ebglyss- lebrikizumab-lbkz injection, solution [package insert]. DailyMed.

                          Eli Lilly and Company. (2024). Instructions for use: Ebglyss™ [EHB-glihs] (lebrikizumab-lbkz) injection, for subcutaneous use single-dose prefilled pen.

                           Eli Lilly and Company. (2024). Instructions for use: Ebglyss™ [EHB-glihs] (lebrikizumab-lbkz) injection, for subcutaneous use single-dose prefilled syringe with needle shield.

                          National Eczema Society. (n.d.). Topical steroids.

                          National Eye Institute. (2024). Pink eye.

                          Schleehauf, B. (2024). How to treat eczema during pregnancy. American Academy of Dermatology Association.

                          Silverberb, J. I., et al. (2023). Two phase 3 trials of lebrikizumab for moderate-to-severe atopic dermatitis. The New England Journal of Medicine.

                          U.S. Department of Health and Human Services. (2022). Vaccine types.

                          U.S. Food and Drug Administration. (2021). Safely using sharps (needles and syringes) at home, at work and on travel.

                          Wollenberg, A., et al. (2012). Long term treatment concepts and proactive therapy for atopic eczema. Annals of Dermatology.

                          GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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