Key takeaways
Olanzapine (Zyprexa) and lithium (Lithobid) are both used to treat bipolar disorder, but they have some key differences. Olanzapine is an atypical antipsychotic that can also treat schizophrenia and certain types of depression when combined with fluoxetine (Prozac). It works by balancing chemicals like dopamine and serotonin in the brain. Lithium, on the other hand, is a mood stabilizer that helps manage manic episodes and long-term maintenance of bipolar disorder. It’s not fully understood how lithium works, but it’s thought to affect brain chemicals that regulate mood. Olanzapine is typically taken once daily and is available in both oral and injectable forms, while lithium is taken 2 to 3 times a day and comes in various oral forms, including tablets and liquid. Olanzapine can cause weight gain and sleepiness, whereas lithium can lead to side effects like shakiness, thirst, and the need for regular blood tests to monitor for toxicity. Both medications are available as lower-cost generics.
