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Xopenex vs. Atrovent HFA

Head-to-head comparisons of medication uses, side effects, warnings, and more.

Key takeaways

Xopenex (levalbuterol) and Atrovent HFA (ipratropium) are both used to help with breathing problems, but they work in different ways and treat different conditions. Xopenex is a short-acting beta agonist (SABA) that helps relax the muscles in your lungs to open up your airways, making it easier to breathe. It's used for sudden wheezing or shortness of breath in people with asthma and is inhaled through a nebulizer. On the other hand, Atrovent is an anticholinergic medication and is used for the maintenance treatment of chronic obstructive pulmonary disease (COPD). Xopenex is typically used three times a day, while Atrovent is used four times a day. Xopenex is available as a generic, while Atrovent is only available as a brand name medication. Common side effects of Xopenex include headache and sore throat, while Atrovent can cause a cough and dry mouth.

Levalbuterol

(Xopenex)

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Atrovent HFA

(ipratropium)

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Summary for Xopenex

Prescription only

Levalbuterol inhalation solution (also known by its brand name, Xopenex) is a short-acting beta agonist (SABA). It's used to treat and prevent sudden wheezing or shortness of breath in people with certain breathing problems, such as asthma. This medication is for adults and children ages 6 years and older. Levalbuterol (Xopenex) inhalation solution is inhaled through the mouth with a nebulizer machine. Side effects of this medication include headache, sore throat, and runny nose. It's available as a lower-cost generic.

Indications for Xopenex

  • Treatment or prevention of wheezing or tightening of airways in people ages 6 years and older with certain types of lung problems (e.g., asthma)

Pros and Cons for Xopenex

Pros

  • Works well for relieving wheezing or shortness of breath
  • Quickly opens up the airways
  • Can use for children as young as 6 years old

Cons

  • Takes about 5 to 15 minutes to take the whole dose
  • Need to use with a nebulizer machine, which isn't ideal for someone who is traveling
  • Need to inhale 3 times daily, so not a long-acting medication

Common Side Effects for Xopenex

Ages 12 years and older:

  • Viral infection (7-12%)
  • Runny nose (3-11%)
  • Nervousness (3-10%)

Ages 6 to 11 years:

  • Headache (8-12%)
  • Runny nose (6-10%)
  • Sore throat (3-10%)
  • Asthma (6-9%)
  • Viral infection (8-9%)
  • Rash (up to 8%)
  • Diarrhea (2-6%)

Warnings for Xopenex

  • Breathing problems
  • Heart problems
  • Allergic reactions
  • Low potassium in the blood
  • Only take as directed

Summary for Atrovent HFA

Prescription only

Atrovent HFA (ipratropium) is a short-acting inhaled anticholinergic medication used to help with difficulty breathing in people with chronic obstructive pulmonary disease (COPD). This medication comes in an inhaler. Typically, you breathe in 2 inhalations, 4 times a day. You should use Atrovent HFA (ipratropium) regularly every day in order it for it to keep your COPD symptoms under control. It's not meant to be used as a rescue inhaler.

Indications for Atrovent HFA

Pros and Cons for Atrovent HFA

Pros

  • Works well as a maintenance treatment for COPD
  • Small inhaler, so easy to take with you, compared to the nebulized ipratropium
  • Not many interactions with other medications

Cons

  • Need to use 2 puffs (inhalations) every 4 hours
  • Not a rescue inhaler
  • It's not completely clear how safe it is for pregnant or breastfeeding females

Common Side Effects for Atrovent HFA

  • Cough and other symptoms of bronchitis (10-23%)
  • Worsened COPD symptoms (8-23%)
  • Trouble breathing (7-8%)
  • Tiredness, chills, and other flu-like symptoms (4-8%)
  • Headache (6-7%)
  • Back pain (2-7%)

Warnings for Atrovent HFA

  • Severe allergic reactions
  • Narrowing of your airways (bronchospasm)
  • Risk of eye and vision problems
  • Trouble urinating

Prices with our coupons for Xopenex vs. Atrovent HFA

Price Card Drug Icon
Levalbuterol25 vials / 3ml of 1.25mg/3ml
$24.25$170.01
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Ipratropium25 vials / 2.5ml of 0.02%
$15.84$24.84
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