Key takeaways
Bupropion (Wellbutrin) and amitriptyline are both medications used to treat depression, but they belong to different drug classes and have distinct characteristics. Bupropion is an atypical antidepressant that works by boosting norepinephrine and dopamine levels in the brain, while amitriptyline is a tricyclic antidepressant (TCA) that raises serotonin and norepinephrine levels. Bupropion is available in both brand and lower-cost generic forms, whereas amitriptyline is only available as a generic since its brand name Elavil is no longer on the market. Bupropion is less likely to cause weight gain and sexual side effects compared to other antidepressants, but it can increase the risk of seizures and is not recommended for people with a history of seizures or eating disorders. On the other hand, amitriptyline can cause significant side effects like sleepiness and weight gain, and it has many drug interactions. Additionally, amitriptyline is often used off-label for nerve pain and migraine prevention, while bupropion is also used to treat seasonal affective disorder. Both medications can take several weeks to show their full effects and should not be stopped abruptly to avoid withdrawal symptoms.
