Key takeaways
Wakix (pitolisant) and Adderall (dextroamphetamine/amphetamine salts) are both used to treat narcolepsy, but they work in different ways and have different uses. Wakix is a histamine-3 (H3) receptor antagonist/inverse agonist that helps with excessive daytime sleepiness and cataplexy in adults with narcolepsy. It is not a controlled substance and is taken once a day in the morning. Common side effects include headache, nausea, and trouble sleeping. On the other hand, Adderall is a stimulant that treats both ADHD and narcolepsy in adults and children. Adderall is a Schedule II controlled substance, meaning it has a high risk of misuse and dependence. It’s taken once a day and common side effects include trouble sleeping and loss of appetite. Unlike Wakix, Adderall has a generic form available, making it a lower-cost option.
