Key takeaways
Tenofovir disoproxil fumarate (Viread) and abacavir/lamivudine (Epzicom) are both antiretroviral medications used to treat HIV. However, they belong to different medication classes and have distinct uses and characteristics. Both medicsations must be used with other HIV antivirals for the treatment of HIV. Tenofovir disoproxil fumarate (Viread) is a nucleoside reverse transcriptase inhibitor (NRTI) that is also approved for treating chronic hepatitis B, while abacavir/lamivudine (Epzicom) is a combination of two NRTIs used solely for HIV treatment. Viread is available as a tablet and a powder, whereas Epzicom is only available as a tablet. Both medications are taken once daily, but Viread's dosing can be adjusted based on weight, especially in children, while Epzicom has a fixed dose for those over 55 lbs. Viread is available as a generic, which may be more affordable, and it can cause side effects like rash, diarrhea, and headache. Epzicom, also available as a generic, requires a genetic test for HLA-B 5701 due to the risk of severe allergic reactions. Additionally, Epzicom may increase the risk of heart attacks, especially in those with existing heart conditions. Both medications can worsen hepatitis B if stopped suddenly, so it's important to follow your healthcare provider's instructions carefully.
